論文 - 詳細
| RRC ID | 84114 |
|---|---|
| 著者 | Mossadeq LE, Bellutti L, Borgne RL, Canman JC, Pintard L, Verbavatz JM, Askjaer P, Dumont J. |
| タイトル | An interkinetic envelope surrounds chromosomes between meiosis I and II in C. elegans oocytes. |
| ジャーナル | bioRxiv |
| Abstract |
At the end of cell division, the nuclear envelope reassembles around the decondensing chromosomes. Female meiosis culminates in two consecutive cell divisions of the oocyte, meiosis I and II, which are separated by a brief transition phase known as interkinesis. Due to the absence of chromosome decondensation and the suppression of genome replication during interkinesis, it has been widely assumed that the nuclear envelope does not reassemble between meiosis I and II. By analyzing interkinesis in C. elegans oocytes, we instead show that an atypical structure made of two lipid bilayers, which we termed the interkinetic envelope, surrounds the surface of the segregating chromosomes. The interkinetic envelope shares common features with the nuclear envelope but also exhibits specific characteristics that distinguish it, including its lack of continuity with the endoplasmic reticulum, unique protein composition, assembly mechanism, and function in chromosome segregation. These distinct attributes collectively define the interkinetic envelope as a unique and specialized structure that has been previously overlooked. |
| 公開日 | 2024-10-21 |
| DOI | 10.1101/2024.10.19.619195 |
| PII | 2024.10.19.619195 |
| PMID | 39484525 |
| PMC | PMC11526925 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1582 tm2886 |