論文 - 詳細
| RRC ID | 84124 |
|---|---|
| 著者 | Erinjeri AP, Wang X, Williams R, Chiozzi RZ, Thalassinos K, Labbadia J. |
| タイトル | HSF-1 promotes longevity through ubiquilin-1-dependent mitochondrial network remodelling. |
| ジャーナル | Nat Commun |
| Abstract |
Increased activity of the heat shock factor, HSF-1, suppresses proteotoxicity and enhances longevity. However, the precise mechanisms by which HSF-1 promotes lifespan are unclear. Using an RNAi screen, we identify ubiquilin-1 (ubql-1) as an essential mediator of lifespan extension in worms overexpressing hsf-1. We find that hsf-1 overexpression leads to transcriptional downregulation of all components of the CDC-48-UFD-1-NPL-4 complex, which is central to both endoplasmic reticulum and mitochondria associated protein degradation, and that this is complemented by UBQL-1-dependent turnover of NPL-4.1. As a consequence, mitochondrial network dynamics are altered, leading to increased lifespan. Together, our data establish that HSF-1 mediates lifespan extension through mitochondrial network adaptations that occur in response to down-tuning of components associated with organellar protein degradation pathways. |
| 巻・号 | 15(1) |
| ページ | 9797 |
| 公開日 | 2024-11-12 |
| DOI | 10.1038/s41467-024-54136-x |
| PII | 10.1038/s41467-024-54136-x |
| PMID | 39532882 |
| PMC | PMC11557981 |
| MeSH | Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Endoplasmic Reticulum / metabolism Longevity* / genetics Mitochondria* / metabolism RNA Interference Transcription Factors* / genetics Transcription Factors* / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 41 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1574 |