| RRC ID |
84137
|
| Author |
Chen L, Harris N, Sengupta P.
|
| Title |
The AFD-expressed SRTX-1 GPCR does not contribute to AFD thermosensory functions.
|
| Journal |
MicroPubl Biol
|
| Abstract |
Temperature experience-regulated gene expression changes have been shown to underlie long-term adaptation of the response threshold of the AFD thermosensory neuron pair, and contribute to thermotaxis behavioral plasticity in C. elegans . We previously showed that the SRTX-1 GPCR is expressed primarily in AFD and is localized to their sensory endings. Here we find that SRTX-1 levels are regulated by the animal's temperature experience. However, loss or overexpression of srtx-1 does not affect thermotaxis behaviors or examined temperature-evoked calcium responses in AFD. Our observations suggest that SRTX-1 may modulate AFD responses and behavior under defined temperature conditions, or in response to specific environmental stimuli.
|
| Volume |
2024
|
| Published |
2024-1-1
|
| DOI |
10.17912/micropub.biology.001382
|
| PMID |
39611104
|
| PMC |
PMC11603155
|
| Resource |
| C.elegans |
tm2064 |
