| RRC ID |
84147
|
| Author |
Pender CL, Dishart JG, Gildea HK, Nauta KM, Page EM, Siddiqi TF, Cheung SS, Joe L, Burton NO, Dillin A.
|
| Title |
Perception of a pathogenic signature initiates intergenerational protection.
|
| Journal |
Cell
|
| Abstract |
Transmission of immune responses from one generation to the next represents a powerful adaptive mechanism to protect an organism's descendants. Parental infection by the natural C. elegans pathogen Pseudomonas vranovensis induces a protective response in progeny, but the bacterial cues and intergenerational signal driving this response were previously unknown. Here, we find that animals activate a protective stress response program upon exposure to P. vranovensis-derived cyanide and that a metabolic byproduct of cyanide detoxification, β-cyanoalanine, acts as an intergenerational signal to protect progeny from infection. Remarkably, this mechanism does not require direct parental infection; rather, exposure to pathogen-derived volatiles is sufficient to enhance the survival of the next generation, indicating that parental surveillance of environmental cues can activate a protective intergenerational response. Therefore, the mere perception of a pathogen-derived toxin, in this case cyanide, can protect an animal's progeny from future pathogenic challenges.
|
| Volume |
188(3)
|
| Pages |
594-605.e10
|
| Published |
2025-2-6
|
| DOI |
10.1016/j.cell.2024.11.026
|
| PII |
S0092-8674(24)01342-4
|
| PMID |
39721586
|
| MeSH |
Alanine / analogs & derivatives
Alanine / metabolism
Animals
Caenorhabditis elegans* / immunology
Caenorhabditis elegans* / microbiology
Cyanides / metabolism
Nitriles / metabolism
Pseudomonas* / metabolism
Pseudomonas* / pathogenicity
Pseudomonas Infections / immunology
|
| Resource |
| C.elegans |
tm2182 |
