論文 - 詳細
| RRC ID | 84154 |
|---|---|
| 著者 | Donato A, Ritchie FK, Lu L, Wadia M, Martinez-Marmol R, Kaulich E, Sankorrakul K, Lu H, Coakley S, Coulson EJ, Hilliard MA. |
| タイトル | OSP-1 protects neurons from autophagic cell death induced by acute oxidative stress. |
| ジャーナル | Nat Commun |
| Abstract |
Oxidative stress, caused by the accumulation of reactive oxygen species (ROS), is a pathological factor in several incurable neurodegenerative conditions as well as in stroke. However, our knowledge of the genetic elements that can be manipulated to protect neurons from oxidative stress-induced cell death is still very limited. Here, using Caenorhabditis elegans as a model system, combined with the optogenetic tool KillerRed to spatially and temporally control ROS generation, we identify a previously uncharacterized gene, oxidative stress protective 1 (osp-1), that protects C. elegans neurons from oxidative damage. Using rodent and human cell cultures, we also show that the protective effect of OSP-1 extends to mammalian cells. Moreover, we demonstrate that OSP-1 functions in a strictly cell-autonomous fashion, and that it localizes to the endoplasmic reticulum (ER) where it has an ER-remodeling function. Finally, we present evidence suggesting that OSP-1 may exert its neuroprotective function by influencing autophagy. Our results point to a potential role of OSP-1 in modulating autophagy, and suggest that overactivation of this cellular process could contribute to neuronal death triggered by oxidative damage. |
| 巻・号 | 16(1) |
| ページ | 300 |
| 公開日 | 2025-1-2 |
| DOI | 10.1038/s41467-024-55105-0 |
| PII | 10.1038/s41467-024-55105-0 |
| PMID | 39746999 |
| PMC | PMC11696186 |
| MeSH | Animals Animals, Genetically Modified Autophagic Cell Death* Autophagy Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Endoplasmic Reticulum* / metabolism Humans Mice Neurons* / metabolism Oxidative Stress* Rats Reactive Oxygen Species* / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 36 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1942 tm858 tm10923 |