Reference - Detail
| RRC ID | 84162 |
|---|---|
| Author | Wu Z, Cardona EA, Cohn JA, Pierce JT. |
| Title | Nonapoptotic role of EGL-1 in exopher production and neuronal health in Caenorhabditis elegans. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
While traditionally studied for their proapoptotic functions in activating the caspase, research suggests BH3-only proteins also have other roles such as mitochondrial dynamics regulation. Here, we find that EGL-1, the BH3-only protein in Caenorhabditis elegans, promotes the cell-autonomous production of exophers in adult neurons. Exophers are large, micron-scale vesicles that are ejected from the cell and contain cellular components such as mitochondria. EGL-1 facilitates exopher production potentially through regulation of mitochondrial dynamics. Moreover, an endogenous, low level of EGL-1 expression appears to benefit dendritic health. Our findings provide insights into the role of neuronal BH3-only protein in mitochondrial dynamics, downstream exopher production, and ultimately neuronal health. |
| Volume | 122(2) |
| Pages | e2407909122 |
| Published | 2025-1-14 |
| DOI | 10.1073/pnas.2407909122 |
| PMID | 39786930 |
| PMC | PMC11745333 |
| MeSH | Animals Apoptosis / physiology Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Dendrites / metabolism Dendrites / physiology Exocytosis / physiology Mitochondria / metabolism Mitochondrial Dynamics / physiology Neurons* / metabolism Repressor Proteins |
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1108 tm1133 |