Reference - Detail
| RRC ID | 84192 |
|---|---|
| Author | Zou W, Fan Y, Liu J, Cheng H, Hong H, Al-Sheikh U, Li S, Zhu L, Li R, He L, Tang YQ, Zhao G, Zhang Y, Wang F, Zhan R, Zheng X, Kang L. |
| Title | Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans. |
| Journal | Nat Commun |
| Abstract |
Mechanotransduction channels are widely expressed in both vertebrates and invertebrates, mediating various physiological processes such as touch, hearing and blood-pressure sensing. While previously known mechanotransduction channels in metazoans are primarily cation-selective, we identified Anoctamin-1 (ANOH-1), the C. elegans homolog of mammalian calcium-activated chloride channel ANO1/TMEM16A, as an essential component of a mechanosensory channel complex that contributes to the nose touch mechanosensation in C. elegans. Ectopic expression of either C. elegans or human Anoctamin-1 confers mechanosensitivity to touch-insensitive neurons, suggesting a cell-autonomous role of ANOH-1/ANO1 in mechanotransduction. Additionally, we demonstrated that the mechanosensory function of ANOH-1/ANO1 relies on CIB (calcium- and integrin- binding) proteins. Thus, our results reveal an evolutionarily conserved chloride channel involved in mechanosensory transduction in metazoans, highlighting the importance of anion channels in mechanosensory processes. |
| Volume | 16(1) |
| Pages | 1680 |
| Published | 2025-2-16 |
| DOI | 10.1038/s41467-025-56938-z |
| PII | 10.1038/s41467-025-56938-z |
| PMID | 39956854 |
| PMC | PMC11830769 |
| MeSH | Animals Animals, Genetically Modified Anoctamin-1* / genetics Anoctamin-1* / metabolism Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Chloride Channels* / genetics Chloride Channels* / metabolism Humans Mechanotransduction, Cellular* / physiology Neoplasm Proteins Neurons / metabolism |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm6751 tm4796 tm3377 tm3448 tm4317 tm6214 tm6258 tm6573 tm7120 tm3577 tm4318 tm7837 tm6556 tm6768 tm7876 tm3712 tm4762 tm2749 tm2735 tm6816 tm2415 tm4258 tm1353 tm3268 tm6972 tm10110 tm8844 |