Reference - Detail
| RRC ID | 84297 |
|---|---|
| Author | Umeda T, Yokoyama O, Suzuki M, Kaneshige M, Isa T, Nishimura Y. |
| Title | Future spinal reflex is embedded in primary motor cortex output. |
| Journal | Sci Adv |
| Abstract |
Mammals can execute intended limb movements despite the fact that spinal reflexes involuntarily modulate muscle activity. To generate appropriate muscle activity, the cortical descending motor output must coordinate with spinal reflexes, yet the underlying neural mechanism remains unclear. We simultaneously recorded activities in motor-related cortical areas, afferent neurons, and forelimb muscles of monkeys performing reaching movements. Motor-related cortical areas, predominantly primary motor cortex (M1), encode subsequent afferent activities attributed to forelimb movement. M1 also encodes a subcomponent of muscle activity evoked by these afferent activities, corresponding to spinal reflexes. Furthermore, selective disruption of the afferent pathway specifically reduced this subcomponent of muscle activity, suggesting that M1 output drives muscle activity not only through direct descending pathways but also through the "transafferent" pathway composed of descending plus subsequent spinal reflex pathways. Thus, M1 provides optimal motor output based on an internal forward model that prospectively computes future spinal reflexes. |
| Volume | 10(51) |
| Pages | eadq4194 |
| Published | 2024-12-20 |
| DOI | 10.1126/sciadv.adq4194 |
| PMID | 39693430 |
| PMC | PMC11654683 |
| MeSH | Animals Electromyography Macaca mulatta Male Motor Cortex* / physiology Movement / physiology Muscle, Skeletal / physiology Reflex* / physiology Spinal Cord / physiology |
| IF | 13.117 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Japanese macaques | |