RRC ID 84304
Author Hori Y, Iwaoki H, Mimura K, Nagai Y, Higuchi M, Minamimoto T.
Title Effects of a 5-HT4 receptor antagonist in the caudate nucleus on the performance of macaques in a delayed reward task.
Journal Sci Rep
Abstract Temporal discounting, in which the recipient of a reward perceives the value of that reward to decrease with delay in its receipt, is associated with impulsivity and psychiatric disorders such as depression. Here, we investigate the role of the serotonin 5-HT4 receptor (5-HT4R) in modulating temporal discounting in the macaque dorsal caudate nucleus (dCDh), the neurons of which have been shown to represent temporally discounted value. We first mapped the 5-HT4R distribution in macaque brains using positron emission tomography (PET) imaging and confirmed dense expression of 5-HT4R in the dCDh. We then examined the effects of a specific 5-HT4R antagonist infused into the dCDh. Blockade of 5-HT4R significantly increased error rates in a goal-directed delayed reward task, indicating an increase in the rate of temporal discounting. This increase was specific to the 5-HT4R blockade because saline controls showed no such effect. The results demonstrate that 5-HT4Rs in the dCDh are involved in reward-evaluation processes, particularly in the context of delay discounting, and suggest that serotonergic transmission via 5-HT4R may be a key component in the neural mechanisms underlying impulsive decisions, potentially contributing to depressive symptoms.
Volume 14(1)
Pages 19619
Published 2024-8-23
DOI 10.1038/s41598-024-70414-6
PII 10.1038/s41598-024-70414-6
PMID 39179718
PMC PMC11344137
MeSH Animals Behavior, Animal / drug effects Caudate Nucleus* / diagnostic imaging Caudate Nucleus* / drug effects Caudate Nucleus* / metabolism Delay Discounting* / drug effects Impulsive Behavior / drug effects Macaca Macaca mulatta Male Positron-Emission Tomography* Receptors, Serotonin, 5-HT4* / metabolism Reward* Serotonin 5-HT4 Receptor Antagonists* / pharmacology
IF 3.998
Resource
Japanese macaques