Reference - Detail
| RRC ID | 84305 |
|---|---|
| Author | Frey T, Murakami T, Maki K, Kawaue T, Tani N, Sugai A, Nakazawa N, Ishiguro KI, Adachi T, Kengaku M, Ohki K, Gotoh Y, Kishi Y. |
| Title | Age-associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex. |
| Journal | Aging Cell |
| Abstract |
Neurons decline in their functionality over time, and age-related neuronal alterations are associated with phenotypes of neurodegenerative diseases. In nonneural tissues, an infolded nuclear shape has been proposed as a hallmark of aged cells and neurons with infolded nuclei have also been reported to be associated with neuronal activity. Here, we performed time-lapse imaging in the visual cortex of Nex-Cre;SUN1-GFP mice. Nuclear infolding was observed within 10 min of stimulation in young nuclei, while the aged nuclei were already infolded pre-stimulation and showed reduced dynamics of the morphology. In young nuclei, the depletion of the stimuli restored the nucleus to a spherical shape and reduced the dynamic behavior, suggesting that nuclear infolding is a reversible process. We also found the aged nucleus to be stiffer than the young one, further relating to the age-associated loss of nuclear shape dynamics. We reveal temporal changes in the nuclear shape upon external stimulation and observe that these morphological dynamics decrease with age. |
| Volume | 22(9) |
| Pages | e13925 |
| Published | 2023-9-1 |
| DOI | 10.1111/acel.13925 |
| PMID | 37476844 |
| PMC | PMC10497821 |
| MeSH | Animals Mice Neurons* Visual Cortex* / physiology |
| IF | 7.238 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 25 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Aged mice | 加齢マウス |