| RRC ID |
84313
|
| Author |
Imanaka T, Takezawa K, Kujime Y, Kitakaze H, Tsujimura G, Kuribayashi S, Sekii Y, Ueda N, Fukuhara S, Kiuchi H, Negoro H, Nonomura N.
|
| Title |
Decreased nitric oxide production is a novel therapeutic target for salt-induced nocturnal polyuria in aging.
|
| Journal |
Sci Rep
|
| Abstract |
Nocturnal polyuria is a major cause of nocturia, which affects quality of life. Aging-related decreases in nitric oxide production have been reported to contribute to salt-induced nocturnal polyuria. We posited that enhanced nitric oxide production from exercise could mitigate salt-induced nocturnal polyuria. To validate, we assessed the impact of 4 weeks of moderate-intensity exercise on intrarenal renin-angiotensin system activity and salt-induced polyuria during inactive periods in 80-week-old mice. The moderate-intensity exercise group (Mod-Ex) had increased nitric oxide production and suppressed intrarenal renin-angiotensin system compared to the sedentary group (Sed) (renal angiotensinogen level: Sed vs. Mod-Ex, 1.101 ± 0.077 vs. 0.630 ± 0.048 arbitrary unit, P = 0.002). This exercise also alleviated salt-induced polyuria during inactive periods (diurnal polyuria index: Sed vs. Mod-Ex, 0.292 ± 0.027 vs. 0.193 ± 0.023, P = 0.018). These effects were neutralized by suppression of nitric oxide production by oral administration of Nω-Nitro-L-arginine methyl ester hydrochloride, an nitric oxide synthesis inhibitor. These findings indicate that exercise-induced improvements in salt-induced polyuria during inactive periods are caused by increases in nitric oxide production. In summary, increasing nitric oxide production may serve as a treatment method for salt-induced nocturnal polyuria in older adults.
|
| Volume |
15(1)
|
| Pages |
3589
|
| Published |
2025-1-28
|
| DOI |
10.1038/s41598-025-86526-6
|
| PII |
10.1038/s41598-025-86526-6
|
| PMID |
39875406
|
| PMC |
PMC11775298
|
| MeSH |
Aging* / metabolism
Animals
Male
Mice
Mice, Inbred C57BL
Nitric Oxide* / biosynthesis
Nitric Oxide* / metabolism
Nocturia* / chemically induced
Nocturia* / metabolism
Nocturia* / therapy
Physical Conditioning, Animal
Polyuria* / chemically induced
Polyuria* / metabolism
Polyuria* / therapy
Renin-Angiotensin System / drug effects
Sodium Chloride, Dietary / adverse effects
|
| IF |
3.998
|
| Resource |
| Aged mice |
加齢マウス |
