論文 - 詳細
| RRC ID | 84344 |
|---|---|
| 著者 | Seki K, Tanaka T, Shimoda E, Tanio S, Yanagita RC, Miyazaki T, Tokumoto K, Tazawa T, Osaki-Oka K, Ishihara A. |
| タイトル | Identification of sesquiterpene aldehydes as volatile antifungal compounds in Phaeolepiota aurea culture filtrate. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The culture filtrate extract of golden bootleg (Phaeolepiota aurea) exhibited strong antifungal activity in a bioassay for volatile compounds. Purification of active compounds through silica gel column chromatography and high performance liquid chromatography isolated two compounds, 1 and 2, with molecular weights of 234 and 259, respectively, as confirmed by mass spectrometry. Nuclear magnetic resonance analysis identified these compounds as new sesquiterpenoids with the α-bourbonene skeleton. Both compounds had an aldehyde group, while 2 possessed a cyanohydrin group. These compounds were named phaeolep aldehydes A (1) and B (2). Phaeolep aldehyde A inhibited hyphae elongation of Penicillium citrinum, Aspergillus niger, Cladosporium sphaerospermum, and Alternaria brassicicola at 10 ppm, but did not exhibit any antibacterial activity. In contrast, phaeolep aldehyde B exhibited potent inhibitory effects on the spore germination of Pe. citrinum, achieving 58.2% inhibition at 0.25 ppm, outperforming phaeolep aldehyde A, which exhibited 25.7% inhibition at 10 ppm. |
| 巻・号 | 88(12) |
| ページ | 1395-1402 |
| 公開日 | 2024-11-22 |
| DOI | 10.1093/bbb/zbae125 |
| PII | 7750048 |
| PMID | 39237456 |
| MeSH | Aldehydes* / chemistry Aldehydes* / isolation & purification Aldehydes* / pharmacology Antifungal Agents* / chemistry Antifungal Agents* / isolation & purification Antifungal Agents* / pharmacology Ascomycota / chemistry Ascomycota / drug effects Hyphae / drug effects Hyphae / growth & development Microbial Sensitivity Tests Penicillium / chemistry Penicillium / drug effects Sesquiterpenes* / chemistry Sesquiterpenes* / isolation & purification Sesquiterpenes* / pharmacology Spores, Fungal / drug effects Volatile Organic Compounds / chemistry Volatile Organic Compounds / isolation & purification Volatile Organic Compounds / pharmacology |
| IF | 1.516 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| きのこ | TUFC 30232 |