| RRC ID |
84800
|
| Author |
Kobayashi K, Tejima R, Nagai K, Seki R, Hosoya T, Une Y, Shigeno S, Tomoda H, Ohshiro T.
|
| Title |
Paranazzamides A and B, new cyclic dipeptides containing a C7-prenylated tryptophan, produced by pathogenic reptile fungi Paranannizziopsis sp. UH-21.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
Two new cyclic dipeptides, paranazzamides A (1) and B (2) containing a C7-prenylated tryptophan, were isolated from a culture broth of snake fungal disease-isolate Paranannizziopsis sp. UH-21. This is the first report on the new secondary metabolites from Paranannizziopsis sp. The planar structures of 1 and 2 were elucidated using various spectroscopic techniques including MS and 1D/2D NMR. The absolute configuration of 1 was assigned by comparison with the synthesized compound. Compounds 1 and 2 exhibited no antifungal activity, no antibacterial activity, and no cytotoxic activity even at a concentration of 128 µg ml-1, whereas 1 and 2 exhibited amphotericin B potentiating activity against Candida auris in combination treatment.
|
| Volume |
77(7)
|
| Pages |
403-411
|
| Published |
2024-7-1
|
| DOI |
10.1038/s41429-024-00725-3
|
| PII |
10.1038/s41429-024-00725-3
|
| PMID |
38750250
|
| MeSH |
Amphotericin B / pharmacology
Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification
Antifungal Agents / pharmacology
Candida / drug effects
Dipeptides* / chemistry
Dipeptides* / isolation & purification
Dipeptides* / pharmacology
Humans
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Peptides, Cyclic* / chemistry
Peptides, Cyclic* / isolation & purification
Peptides, Cyclic* / pharmacology
Prenylation
Tryptophan* / chemistry
Tryptophan* / metabolism
|
| Resource |
| General Microbes |
JCM15430 |
