Reference - Detail
| RRC ID | 84801 |
|---|---|
| Author | Yagi A, Fujiwara M, Sato M, Abe Y, Uchida R. |
| Title | New liposidomycin congeners produced by Streptomyces sp. TMPU-20A065, anti-Mycobacterium avium complex agents with therapeutic efficacy in a silkworm infection model. |
| Journal | J Antibiot (Tokyo) |
| Abstract |
Three new liposidomycin congeners (1, 2, and 4), together with 14 known liposidomycins (3 and 5-17), were isolated from the culture broth of Streptomyces sp. TMPU-20A065 as anti-Mycobacterium avium complex agents. The structures of liposidomycins were elucidated by spectroscopic analyses, including NMR and MS. Compounds 1, 2, and 4 belong to type-I liposidomycin-containing sulfate groups and methylglutaric acid, each with a different acyl side chain in the structure. Compounds 1-17 exhibited in vitro anti-M. avium and M. intracellulare activities with MIC values ranging between 2.0 and 64 μg ml-1. Furthermore, 1-17 exerted potent therapeutic effects in an in vivo-mimic silkworm infection model with ED50 values ranging between 0.12 and 3.7 μg larva-1 g-1. |
| Volume | 77(7) |
| Pages | 412-421 |
| Published | 2024-7-1 |
| DOI | 10.1038/s41429-024-00724-4 |
| PII | 10.1038/s41429-024-00724-4 |
| PMID | 38720140 |
| PMC | PMC11208132 |
| MeSH | Animals Anti-Bacterial Agents* / chemistry Anti-Bacterial Agents* / isolation & purification Anti-Bacterial Agents* / pharmacology Bombyx* / microbiology Disease Models, Animal Magnetic Resonance Spectroscopy Microbial Sensitivity Tests* Molecular Structure Mycobacterium avium Complex* / drug effects Streptomyces* / chemistry Streptomyces* / metabolism |
| Resource | |
| General Microbes | JCM15430 JCM6384 |