Reference - Detail
| RRC ID | 84803 |
|---|---|
| Author | Tang LF, Jihuo WL, Shi PD, Mei CX, Zhao ZK, Chen Y, Di YT, Hao XJ, Cao M, Zhao Y, Che YY. |
| Title | Cytotoxic glutarimide-containing polyketides isolated from Streptomyces sp. JCM 4793. |
| Journal | J Antibiot (Tokyo) |
| Abstract |
Glutarimide-containing polyketides usually exhibit anti-fungi activity, which was well exampled by cycloheximide. In our work, three new polyketide structures, 12-amidestreptimidone (1), 12-carboxylstreptimidone (2) and 3-(5S,8R)-(2-amino-2-oxoethyl-2'-methoxy-2'-oxoethyl)-8,10-dimethyl-7-oxododeca-5-hydroxy-9E,11-diolefin (3) were isolated from Streptomyces sp. JCM 4793. 3 without the glutarimide moiety is not active against fungi as expected, while 1 bearing the amide moiety is much more active than its carboxylic form 2. Here we report the isolation, structural elucidation, antifungal activity, and proposed biosynthesis pathway of 1-3. |
| Volume | 77(9) |
| Pages | 627-633 |
| Published | 2024-9-1 |
| DOI | 10.1038/s41429-024-00743-1 |
| PII | 10.1038/s41429-024-00743-1 |
| PMID | 38816449 |
| MeSH | Antifungal Agents* / chemistry Antifungal Agents* / isolation & purification Antifungal Agents* / pharmacology Humans Microbial Sensitivity Tests Molecular Structure Piperidones / chemistry Piperidones / isolation & purification Piperidones / pharmacology Polyketides* / chemistry Polyketides* / isolation & purification Polyketides* / pharmacology Streptomyces* / chemistry Streptomyces* / metabolism |
| Resource | |
| General Microbes | JCM4793 |