Reference - Detail
| RRC ID | 84842 |
|---|---|
| Author | Kano R, Yamada T, Tamura T, Makimura K. |
| Title | Is milbemycin a game changer against antifungal drug-resistant mycoses? |
| Journal | Med Mycol |
| Abstract |
Milbemycin oximes are macrocyclic lactones that have a broad spectrum of activity against nematode infection in animals. They are known to block drug efflux, which increases the susceptibility of fungi to azoles. We investigated the effects of milbemycin on the azole susceptibility of fungi (Aspergillus fumigatus, Candida albicans, C. auris, Cryptococcus neoformans, and Trichophyton rubrum). To screen for changes in azole susceptibility, fungal growth was tested on a culture medium containing 1 μg/ml milbemycin. The results showed that milbemycin increased the azole susceptibility of azole-resistant strains of C. albicans, C. auris, C. neoformans, and T. rubrum. Thus, milbemycin might be useful against antifungal drug-resistant strains. |
| Volume | 62(2) |
| Published | 2024-1-27 |
| DOI | 10.1093/mmy/myae003 |
| PII | 7591307 |
| PMID | 38285608 |
| MeSH | Animals Antifungal Agents / pharmacology Antifungal Agents / therapeutic use Azoles / pharmacology Cryptococcus neoformans* Drug Resistance, Fungal Macrolides* Microbial Sensitivity Tests / veterinary Mycoses* / veterinary |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM15448 |