論文 - 詳細
| RRC ID | 84843 |
|---|---|
| 著者 | Wu WG, Luk KS, Hung MF, Tsang WY, Lee KP, Lam BH, Cheng KL, Cheung WS, Tang HL, To WK. |
| タイトル | Antifungal efficacy of natural antiseptic products against Candida auris. |
| ジャーナル | Med Mycol |
| Abstract |
Candida auris is an emerging fungal pathogen responsible for healthcare-associated infections and outbreaks with high mortality around the world. It readily colonizes the skin, nares, respiratory and urinary tract of hospitalized patients, and such colonization may lead to invasive Candida infection in susceptible patients. However, there is no recommended decolonization protocol for C. auris by international health authorities. The aim of this study is to evaluate the susceptibility of C. auris to commonly used synthetic and natural antiseptic products using an in vitro, broth microdilution assay. Synthetic antiseptics including chlorhexidine, povidone-iodine, and nystatin were shown to be fungicidal against C. auris. Among the natural antiseptics tested, tea tree oil and manuka oil were both fungicidal against C. auris at concentrations less than or equal to 1.25% (v/v). Manuka honey inhibited C. auris at 25% (v/v) concentrations. Among the commercial products tested, manuka body wash and mouthwash were fungicidal against C. auris at concentrations less than or equal to 0.39% (w/v) and 6.25% (v/v) of products as supplied for use, respectively, while tea tree body wash and MedihoneyTM wound gel demonstrated fungistatic properties. In conclusion, this study demonstrated good in vitro antifungal efficacy of tea tree oil, manuka oil, manuka honey, and commercially available antiseptic products containing these active ingredients. Future studies are warranted to evaluate the effectiveness of these antiseptic products in clinical settings. |
| 巻・号 | 62(7) |
| 公開日 | 2024-7-4 |
| DOI | 10.1093/mmy/myae060 |
| PII | 7700696 |
| PMID | 38936838 |
| MeSH | Anti-Infective Agents, Local* / pharmacology Antifungal Agents* / pharmacology Candida auris* / drug effects Chlorhexidine / pharmacology Honey Humans Leptospermum / chemistry Microbial Sensitivity Tests* Tea Tree Oil / pharmacology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.5 |
| リソース情報 | |
| 一般微生物 | JCM15448 |