| RRC ID |
84895
|
| 著者 |
Wang Y, Li Y, Lv L, Zhu L, Hong L, Wang X, Zhang Y, Wang X, Diao H.
|
| タイトル |
Faecal hsa-miR-7704 inhibits the growth and adhesion of Bifidobacterium longum by suppressing ProB and aggravates hepatic encephalopathy.
|
| ジャーナル |
NPJ Biofilms Microbiomes
|
| Abstract |
Both gut microbiome and microRNAs (miRNAs) play a role in the development of hepatic encephalopathy (HE). However, the functional link between the microbiome and host-derived miRNAs in faeces remains poorly understood. In the present study, patients with HE had an altered gut microbiome and faecal miRNAs compared with patients with chronic hepatitis B. Transferring faeces and faecal miRNAs from patients with HE to the recipient mice aggravated thioacetamide-induced HE. Oral gavage of hsa-miR-7704, a host-derived miRNA highly enriched in faeces from patients with HE, aggravated HE in mice in a microbiome-dependent manner. Mechanistically, hsa-miR-7704 inhibited the growth and adhesion of Bifidobacterium longum by suppressing proB. B. longum and its metabolite acetate alleviated HE by inhibiting microglial activation and ammonia production. Our findings reveal the role of miRNA-microbiome axis in HE and suggest that faecal hsa-miR-7704 are potential regulators of HE progression.
|
| 巻・号 |
10(1)
|
| ページ |
13
|
| 公開日 |
2024-2-24
|
| DOI |
10.1038/s41522-024-00487-8
|
| PII |
10.1038/s41522-024-00487-8
|
| PMID |
38396001
|
| PMC |
PMC10891095
|
| MeSH |
Animals
Bifidobacterium longum* / genetics
Bifidobacterium longum* / metabolism
Feces / microbiology
Hepatic Encephalopathy* / genetics
Hepatic Encephalopathy* / microbiology
Humans
Mice
MicroRNAs* / genetics
MicroRNAs* / metabolism
|
| リソース情報 |
| 一般微生物 |
JCM1217 |
