論文 - 詳細
| RRC ID | 84896 |
|---|---|
| 著者 | Ejima R, Mishima R, Sen A, Yamaguchi K, Mitsuyama E, Kaneko H, Kimura M, Arai S, Muto N, Hiraku A, Kato K, Kuwano Y, Maruyama H, Nakamura M, Iwabuchi N, Nakano M, Odamaki T, Tanaka M. |
| タイトル | The Impact of Fermented Milk Products Containing Bifidobacterium longum BB536 on the Gut Environment: A Randomized Double-Blind Placebo-Controlled Trial. |
| ジャーナル | Nutrients |
| Abstract |
Probiotics, particularly those native to the gut microbiota, have a profound influence on the gut environment. In this study, we conducted a randomized placebo-controlled, double-blind, parallel-group comparison trial to investigate the effects of Bifidobacterium longum BB536 (B. longum BB536) on the fecal microbiota and metabolite compositions in healthy individuals. We compared the effects of fermented milk produced solely with Streptococcus thermophiles and Lactobacillus bulgaricus (placebo group) and fermented milk supplemented with B. longum BB536 (BY group). Our findings revealed a significantly greater relative abundance of Faecalibacterium in the BY group than in the placebo group by the 3rd day, a trend that persisted until the end of the trial on the 17th day. Additionally, the BY group presented significantly increased concentrations of tryptophan (Trp), Indole-3-lactic acid, and Indole-3-aldehyde on the 17th day. A significant positive correlation was observed between the relative abundance of Faecalibacterium and the number of viable B. longum BB536 bacteria in the feces. The concentrations of Trp and Indole-3-acetic acid were also significantly correlated with the number of viable B. longum BB536 bacteria in the feces. Our results suggest that B. longum BB536 intake can modulate the gut microbiota and metabolite profiles, which are general indicators for monitoring the gut environment, potentially conferring health benefits to the host. |
| 巻・号 | 16(21) |
| 公開日 | 2024-10-22 |
| DOI | 10.3390/nu16213580 |
| PII | nu16213580 |
| PMID | 39519413 |
| PMC | PMC11547261 |
| MeSH | Adult Bifidobacterium longum* Cultured Milk Products* / microbiology Double-Blind Method Faecalibacterium Feces* / microbiology Female Gastrointestinal Microbiome* / drug effects Humans Lactobacillus Male Probiotics* Streptococcus thermophilus Tryptophan Young Adult |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 7.0 |
| リソース情報 | |
| 一般微生物 | JCM39207 |