Reference - Detail
| RRC ID | 84981 |
|---|---|
| Author | Gusareva ES, Ghosh AG, Kharkov VN, Khor SS, Zarubin A, Moshkov N, Kalsi N, Ratan A, Heinle CE, Cooke N, Bravi CM, Smolnikova MV, Tereshchenko SY, Kasparov EW, Khitrinskaya I, Marusin A, Razhabov MO, Golubenko MV, Swarovskaya M, Kolesnikov NA, Vagaitseva KV, Eremina ER, Sukhomyasova A, Shtygasheva O, Panicker D, Ang PN, Lee CF, Koh Y, Leong ST, Park C, Lohar SR, Yap ZH, Ng SG, Dacanay J, Drautz-Moses DI, Ramli NAB, Tokunaga K, McGonigle I, Danjoh I, Moreno-Estrada A, Tajima A, Tanabe H, Nakamura Y, Nakagome S, Tatarinova TV, Stepanov VA, Schuster SC, Kim HL. |
| Title | From North Asia to South America: Tracing the longest human migration through genomic sequencing. |
| Journal | Science |
| Abstract |
Genome sequencing of 1537 individuals from 139 ethnic groups reveals the genetic characteristics of understudied populations in North Asia and South America. Our analysis demonstrates that West Siberian ancestry, represented by the Kets and Nenets, contributed to the genetic ancestry of most Siberian populations. West Beringians, including the Koryaks, Inuit, and Luoravetlans, exhibit genetic adaptation to Arctic climate, including medically relevant variants. In South America, early migrants split into four groups-Amazonians, Andeans, Chaco Amerindians, and Patagonians-~13,900 years ago. Their longest migration led to population decline, whereas settlement in South America's diverse environments caused instant spatial isolation, reducing genetic and immunogenic diversity. These findings highlight how population history and environmental pressures shaped the genetic architecture of human populations across North Asia and South America. |
| Volume | 388(6748) |
| Pages | eadk5081 |
| Published | 2025-5-15 |
| DOI | 10.1126/science.adk5081 |
| PMID | 40373127 |
| MeSH | Asia Ethnicity* / genetics Genetic Variation Genetics, Population Genome, Human* Human Migration* / history Humans Siberia / ethnology South America Whole Genome Sequencing |
| IF | 41.846 |
| Resource | |
| Human and Animal Cells | CHP01(HSC0002) CHP02(HSC0003) CHP08(HSC0004) YAN3301(HSC0005) CHP04(HSC0007) YAN3142(HSC0008) CHP06(HSC0009) YAN3119(HSC0010) YAN3140(HSC0011) YAN3143(HSC0012) YAN3150(HSC0014) YAN3245(HSC0015) CHP09(HSC0017) YAN3161(HSC0018) 2C099(HSC0216) YAN3252(HSC0020) PAR13(HSC0315) YAN3268(HSC0021) PAR145(HSC0318) PAR10(HSC0319) YAN3141(HSC0022) PAR98(HSC0320) PAR26(HSC0322) YAN3261(HSC0023) PAR74(HSC0323) YAN3264(HSC0024) PAR107(HSC0324) PAR127(HSC0329) YAN3154(HSC0025) PAR19(HSC0338) PAR142(HSC0344) YAN3286(HSC0026) COL705(HSC0357) CHP07(HSC0028) COL703(HSC0361) PAR15(HSC0379) YAN3280(HSC0029) PAR45(HSC0382) PAR71(HSC0383) YAN3265(HSC0030) PAR53(HSC0385) YAN3242(HSC0032) PAR6(HSC0386) PAR12(HSC0387) 2C092(HSC0033) PAR91(HSC0395) 2C101(HSC0036) 2C089(HSC0041) PAR86(HSC0397) PAR115(HSC0398) PAR110(HSC0400) COL720(HSC0419) COL706(HSC0423) COL711(HSC0424) COL714(HSC0425) COL721(HSC0426) COL723(HSC0427) COL708(HSC0430) COL718(HSC0433) YAN3115(HSC0456) YAN3116(HSC0457) YAN3160(HSC0458) YAN3180(HSC0459) YAN3134(HSC0461) YAN3166(HSC0462) YAN3133(HSC0465) YAN3175(HSC0467) YAN3176(HSC0470) PAR140(HSC0494) PAR141(HSC0502) PAR143(HSC0504) PAR144(HSC0510) 2C012(HSC0044) YAN3285(HSC0060) YAN3206(HSC0065) YAN3244(HSC0093) YAN3275(HSC0094) 2C090(HSC0097) YAN3269(HSC0098) YAN3241(HSC0099) YAN3274(HSC0100) YAN3270(HSC0103) YAN3259(HSC0104) YAN3273(HSC0110) YAN3260(HSC0121) YAN3103(HSC0124) YAN3102(HSC0128) YAN3255(HSC0129) 2C088(HSC0133) 2C087(HSC0134) YAN3136(HSC0136) 2C067(HSC0139) 2C076(HSC0141) 2C093(HSC0183) 2CO94(HSC0191) 2C091(HSC0197) |