| RRC ID |
85042
|
| 著者 |
Iwaide S, Takemae H, Oba M, Owaku K, Kobayashi N, Itoh Y, Kozono T, Hisada M, Miyabe-Nishiwaki T, Watanuki K, Yanai T, Inoue H, Murakami T.
|
| タイトル |
Systemic AL kappa chain amyloidosis in a captive Bornean orangutan (Pongo pygmaeus).
|
| ジャーナル |
Res Vet Sci
|
| Abstract |
Systemic amyloid light-chain (AL) amyloidosis is an infrequent disease in which amyloid fibrils derived from the immunoglobulin light chain are deposited in systemic organs, resulting in functional impairment. This disease has been notably uncommon in animals, and nonhuman primates have not been reported to develop it. In this study, we identified the systemic AL kappa chain amyloidosis in a captive Bornean orangutan (Pongo pygmaeus) and analyzed its pathogenesis. Amyloid deposits were found severely in the submucosa of the large intestine, lung, mandibular lymph nodes, and mediastinal lymph nodes, with milder lesions in the liver and kidney. Mass spectrometry-based proteomic analysis revealed an abundant constant domain of the immunoglobulin kappa chain in the amyloid deposits. Immunohistochemistry further confirmed that the amyloid deposits were positive for immunoglobulin kappa chains. In this animal, AL amyloidosis resulted in severe involvement of the gastrointestinal submucosa and lymph nodes, which is consistent with the characteristics of AL amyloidosis in humans, suggesting that AL amyloid may have a similar deposition mechanism across species. This report enhances the pathological understanding of systemic AL amyloidosis in animals by providing a detailed characterization of this disease based on proteomic analysis.
|
| 巻・号 |
175
|
| ページ |
105315
|
| 公開日 |
2024-8-1
|
| DOI |
10.1016/j.rvsc.2024.105315
|
| PII |
S0034-5288(24)00181-4
|
| PMID |
38838511
|
| MeSH |
Amyloidosis* / pathology
Amyloidosis* / veterinary
Animals
Ape Diseases* / pathology
Female
Immunoglobulin Light-chain Amyloidosis / pathology
Immunoglobulin Light-chain Amyloidosis / veterinary
Immunoglobulin kappa-Chains
Lymph Nodes / pathology
Male
Pongo pygmaeus*
Proteomics
|
| IF |
1.892
|
| リソース情報 |
| GAIN |
id=534 |
