| RRC ID |
85078
|
| Author |
Bogutz AB, Brind'Amour J, Kobayashi H, Jensen KN, Nakabayashi K, Imai H, Lorincz MC, Lefebvre L.
|
| Title |
Evolution of imprinting via lineage-specific insertion of retroviral promoters.
|
| Journal |
Nat Commun
|
| Abstract |
Imprinted genes are expressed from a single parental allele, with the other allele often silenced by DNA methylation (DNAme) established in the germline. While species-specific imprinted orthologues have been documented, the molecular mechanisms underlying the evolutionary switch from biallelic to imprinted expression are unknown. During mouse oogenesis, gametic differentially methylated regions (gDMRs) acquire DNAme in a transcription-guided manner. Here we show that oocyte transcription initiating in lineage-specific endogenous retroviruses (ERVs) is likely responsible for DNAme establishment at 4/6 mouse-specific and 17/110 human-specific imprinted gDMRs. The latter are divided into Catarrhini- or Hominoidea-specific gDMRs embedded within transcripts initiating in ERVs specific to these primate lineages. Strikingly, imprinting of the maternally methylated genes Impact and Slc38a4 was lost in the offspring of female mice harboring deletions of the relevant murine-specific ERVs upstream of these genes. Our work reveals an evolutionary mechanism whereby maternally silenced genes arise from biallelically expressed progenitors.
|
| Volume |
10(1)
|
| Pages |
5674
|
| Published |
2019-12-12
|
| DOI |
10.1038/s41467-019-13662-9
|
| PII |
10.1038/s41467-019-13662-9
|
| PMID |
31831741
|
| PMC |
PMC6908575
|
| MeSH |
Animals
DNA Methylation*
Epigenomics
Evolution, Molecular*
Female
Genomic Imprinting*
Germ Cells
Haplorhini
Humans
Macaca
Male
Mice
Oocytes / metabolism
Pan troglodytes
Primates
Promoter Regions, Genetic / genetics*
Retroviridae / genetics*
Species Specificity
Terminal Repeat Sequences
|
| IF |
12.121
|
| Resource |
| GAIN |
chimpanzee
rhesus macaque |
