論文 - 詳細
| RRC ID | 85099 |
|---|---|
| 著者 | Kimura Y, Kimura M, Miura N, Yoshino Y, Kono H. |
| タイトル | NOD1 deficiency promotes inflammation via autophagic degradation of ASK1. |
| ジャーナル | Commun Biol |
| Abstract |
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a pattern recognition receptor of bacterial peptidoglycans. NOD1 facilitates the elimination of invading intracellular bacteria via autophagy induction. Here, we demonstrate that NOD1 exerts an anti-inflammatory effect mediated via the selective autophagy of host cell protein. In our study of Candida albicans water-soluble fraction (CAWS)-induced coronary arteritis, which is a mouse model of Kawasaki disease, we observed an exacerbated disease phenotype in NOD1-deficient mice. NOD1 deficiency induced a higher expression of inflammatory cytokines via CAWS and CAWS-induced endoplasmic reticulum (ER) stress in bone marrow-derived dendritic cells. Furthermore, exaggerated inflammation was dependent on apoptosis signal-regulated kinase 1 (ASK1). Notably, NOD1 directly interacted with ASK1, inducing selective autophagy of ASK1, which was dependent on ATG16L1, and thus competitively inhibiting ER stress-dependent ASK1 activation. Altogether, these results show that NOD1 modulates excessive inflammatory responses through the upregulation of autophagy. |
| 巻・号 | 8(1) |
| ページ | 781 |
| 公開日 | 2025-5-21 |
| DOI | 10.1038/s42003-025-08213-6 |
| PII | 10.1038/s42003-025-08213-6 |
| PMID | 40399666 |
| PMC | PMC12095521 |
| MeSH | Animals Autophagy* Autophagy-Related Proteins / metabolism Candida albicans Endoplasmic Reticulum Stress Humans Inflammation* / genetics Inflammation* / metabolism MAP Kinase Kinase Kinase 5* / genetics MAP Kinase Kinase Kinase 5* / metabolism Mice Mice, Inbred C57BL Mice, Knockout Nod1 Signaling Adaptor Protein* / deficiency Nod1 Signaling Adaptor Protein* / genetics Nod1 Signaling Adaptor Protein* / metabolism |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | pGedit (RDB16763) |