| RRC ID |
85178
|
| Author |
Hara Y, Nakamura A, Manome T, Takaya A, Takahashi H, Ban S, Yaguchi T, Ishibashi M.
|
| Title |
A new diterpenoid, carneadiol, isolated from Nocardia carnea IFM 12324.
|
| Journal |
J Nat Med
|
| Abstract |
A new diterpenoid, carneadiol (1), with an unprecedented tricyclic carbon skeleton, was isolated from the culture extracts of Nocardia carnea IFM 12324. The structure of compound 1 was elucidated using spectral studies, including various NMR data. The absolute configuration of 1 was determined using X-ray crystallographic analysis with the crystalline sponge method. The biosynthetic gene of compound 1 was deduced, and it was observed that the mRNA of the gene involved in terpenoid cyclization increased significantly in the strain producing compound 1.
|
| Volume |
79(2)
|
| Pages |
435-440
|
| Published |
2025-3-1
|
| DOI |
10.1007/s11418-025-01878-7
|
| PII |
10.1007/s11418-025-01878-7
|
| PMID |
39873975
|
| MeSH |
Crystallography, X-Ray
Diterpenes* / chemistry
Diterpenes* / isolation & purification
Magnetic Resonance Spectroscopy
Molecular Structure
Nocardia* / chemistry
Nocardia* / genetics
Nocardia* / metabolism
|
| IF |
2.055
|
| Resource |
| Pathogenic eukaryotic microorganisms |
Nocardia carnea IFM 12324 |
