| RRC ID |
85183
|
| Author |
Motohashi T, Sekiya M, Sakamoto S, Fukuda K, Nakamura Y, Sasaki M, Tochigi N, Yaguchi T, Kamei K, Kishi K.
|
| Title |
Successful treatment by switching from benralizumab to dupilumab in a patient with allergic bronchopulmonary mycosis caused by Schizophyllumcommune.
|
| Journal |
Respir Investig
|
| Abstract |
A 79-year-old female patient with a history of bronchial asthma was diagnosed with allergic bronchopulmonary aspergillosis. Her symptoms temporarily improved with inhaled corticosteroid/long-acting β2-agonist therapy. However, 10 months after treatment, her asthma symptoms worsened. Sputum culture showed white cotton wool colonies, which were identified as Schizophyllum commune via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and gene sequencing. The patient tested positive for S. commune-specific IgG. Thus, she was diagnosed with Schizophyllum commune-induced allergic bronchopulmonary mycosis. The patient was initially treated with benralizumab. However, it was not effective. After switching to dupilumab, her symptoms and mucus plugs improved.
|
| Volume |
63(3)
|
| Pages |
311-313
|
| Published |
2025-5-1
|
| DOI |
10.1016/j.resinv.2025.02.011
|
| PII |
S2212-5345(25)00022-X
|
| PMID |
40054037
|
| MeSH |
Aged
Antibodies, Monoclonal, Humanized* / administration & dosage
Antibodies, Monoclonal, Humanized* / therapeutic use
Aspergillosis, Allergic Bronchopulmonary* / drug therapy
Aspergillosis, Allergic Bronchopulmonary* / microbiology
Asthma / complications
Drug Substitution*
Female
Humans
Schizophyllum* / immunology
Schizophyllum* / isolation & purification
Treatment Outcome
|
| Resource |
| Pathogenic eukaryotic microorganisms |
Schizophyllum commune IFM 67768 |
