Reference - Detail
| RRC ID | 85196 |
|---|---|
| Author | Kojima H, Watanabe Y, Higo M, Kasuya T, Nonaka K, Iwatsuki M, Sugawara A. |
| Title | Novel Tetrapeptides, Tengupeptins A and B, Produced by Lecanicillium aphanocladii FKI-9593 Fungal Strain. |
| Journal | Chem Biodivers |
| Abstract |
The discovery of novel natural products through the exploration of distinct microorganisms is crucial for advancing drug discovery research. In this study, we focus on a unique environmental resource, microbial masses known as "Tengu-no-Mugimeshi." From the culture broth of Lecanicillium aphanocladii FKI-9593, isolated from Tengu-no-Mugimeshi collected at Mount Kurohime, Nagano Prefecture, Japan, we report the isolation of two novel tetrapeptides, tengupeptins A (1) and B (2), as well as the known compound oosporein. Structural analysis revealed that tengupeptins are composed of four amino acids: L-glutamic acid for 1 (or L-pyroglutamic acid for 2), (Z)-α,β-didehydro tryptophan (ΔZTrp), (Z)-α,β-didehydro-phenylalanine (ΔZPhe), and L-aspartic acid. Notably, dehydroamino acids containing an aromatic moiety conjugated with a double bond connected via two or more consecutive linkages are rare in natural products, and the ΔZTrp-ΔZPhe fragment represents the first example. The isolation of secondary metabolites from filamentous fungi inhabiting unique environments, such as Tengu-no-Mugimeshi, is anticipated to offer significant potential for future research. |
| Volume | 22(5) |
| Pages | e202403050 |
| Published | 2025-5-1 |
| DOI | 10.1002/cbdv.202403050 |
| PMID | 39714384 |
| MeSH | Hypocreales* / chemistry Hypocreales* / metabolism Microbial Sensitivity Tests Molecular Structure Oligopeptides* / chemistry Oligopeptides* / isolation & purification Oligopeptides* / pharmacology |
| IF | 2.039 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic eukaryotic microorganisms | Cryptococcus neoformans IFM 5505 |