Reference - Detail
| RRC ID | 85342 |
|---|---|
| Author | Matsuda K, Ide N, Xu Y, Iijima A, Shibuya A. |
| Title | Type 1 innate lymphoid cell-immature neutrophil axis suppresses acute tissue inflammation. |
| Journal | Nat Commun |
| Abstract |
Immature neutrophils (imNeu) are a minor population of circulating neutrophils that migrate from the bone marrow (BM) into the circulation and inflamed tissues during infection, injury, physical stress, and cancer. However, the underlying mechanism of their mobilization from BM and its pathophysiological significance remains incompletely understood. Here, we show that interferon-gamma (IFN-γ) derived from type 1 innate lymphoid cells (ILC1) enhances the migration of imNeu, but not mature neutrophils, from the BM into inflamed liver tissue with ischemia-reperfusion injury and the blood circulation during polymicrobial sepsis in mice. Mechanistically, the scaffold protein Ahnak, which is specifically expressed in imNeu, underpins Smad7 nuclear translocation in response to IFN-γ, thus downregulating C-X-C chemokine receptor 4 expression critical for neutrophil retention in the BM. Furthermore, imNeu produce interleukin-10 to ameliorate tissue inflammation. Our findings thus reveal the ILC1-imNeu axis that protects tissues from acute inflammation due to injury or microbial infection. |
| Volume | 16(1) |
| Pages | 6574 |
| Published | 2025-7-17 |
| DOI | 10.1038/s41467-025-61504-8 |
| PII | 10.1038/s41467-025-61504-8 |
| PMID | 40675953 |
| PMC | PMC12271315 |
| MeSH | Animals Cell Movement Immunity, Innate* Inflammation* / immunology Inflammation* / pathology Interferon-gamma / immunology Interferon-gamma / metabolism Interleukin-10 / immunology Interleukin-10 / metabolism Liver / immunology Liver / pathology Lymphocytes* / immunology Lymphocytes* / metabolism Male Membrane Proteins / metabolism Mice Mice, Inbred C57BL Mice, Knockout Neutrophils* / immunology Neutrophils* / metabolism Reperfusion Injury / immunology Reperfusion Injury / pathology Sepsis / immunology |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 8 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC01958 |