論文 - 詳細
| RRC ID | 85419 |
|---|---|
| 著者 | Bénard A, Hansen FJ, Uhle F, Klösch B, Czubayko F, Mittelstädt A, Jacobsen A, David P, Podolska MJ, Anthuber A, Swierzy I, Schaack D, Mühl-Zürbes P, Steinkasserer A, Weyand M, Weigand MA, Brenner T, Krautz C, Grützmann R, Weber GF. |
| タイトル | Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming. |
| ジャーナル | Front Immunol |
| Abstract |
RATIONALE:Sepsis, a global health burden, is often complicated by viral infections leading to increased long-term morbidity and mortality. Interleukin-3 (IL-3) has been identified as an important mediator amplifying acute inflammation in sepsis; however, its function in the host response to viral infections during sepsis remains elusive. OBJECTIVES:To investigate the role of IL-3 during viral pneumonia in sepsis. METHODS:We included septic patients from two different cohorts and used in vitro and in vivo assays. The obtained data were substantiated using a second model (SARS-CoV-2 infections). MEASUREMENTS AND MAIN RESULTS:Low plasma IL-3 levels were associated with increased herpes simplex virus (HSV) airway infections in septic patients, resulting in reduced overall survival. Likewise, Il-3-deficient septic mice were more susceptible to pulmonary HSV-1 infection and exhibited higher pulmonary inflammation than control mice. Mechanistically, IL-3 increases innate antiviral immunity by promoting the recruitment of circulating plasmacytoid dendritic cells (pDCs) into the airways and by enhancing pDC-mediated T cell activation upon viral stimulation. Interestingly, the ability of IL-3 to improve adaptive immunity was confirmed in patients with SARS-CoV-2 infections. CONCLUSION:Our study identifies IL-3 as a predictive disease marker for viral reactivation in sepsis and reveals that IL-3 improves antiviral immunity by enhancing the recruitment and the function of pDCs. |
| 巻・号 | 14 |
| ページ | 1140630 |
| 公開日 | 2023-1-1 |
| DOI | 10.3389/fimmu.2023.1140630 |
| PMID | 36911737 |
| PMC | PMC9996195 |
| MeSH | Animals COVID-19* Dendritic Cells Interleukin-3 Lung Mice SARS-CoV-2 Sepsis* T-Lymphocytes |
| IF | 5.085 |
| リソース情報 | |
| 実験動物マウス | RBRC02298 |