論文 - 詳細
| RRC ID | 85472 |
|---|---|
| 著者 | Hozumi A, Totsuka NM, Onodera A, Wang Y, Hamada M, Shiraishi A, Satake H, Horie T, Hotta K, Sasakura Y. |
| タイトル | Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona. |
| ジャーナル | Elife |
| Abstract |
Larvae of the ascidian Ciona initiate metamorphosis tens of minutes after adhesion to a substratum via their adhesive organ. The gap between adhesion and metamorphosis initiation is suggested to ensure the rigidity of adhesion, allowing Ciona to maintain settlement after losing locomotive activity through metamorphosis. The mechanism producing the gap is unknown. Here, by combining gene functional analyses, pharmacological analyses, and live imaging, we propose that the gap represents the time required for sufficient cyclic adenosine monophosphate (cAMP) accumulation to trigger metamorphosis. Not only the Gs pathway but also the Gi and Gq pathways are involved in the initiation of metamorphosis in the downstream signaling cascade of the neurotransmitter GABA, the known initiator of Ciona metamorphosis. The mutual crosstalk of stimulatory and inhibitory G-proteins functions as the accelerator and brake for cAMP production, ensuring the faithful initiation of metamorphosis at an appropriate time and in the right situation. |
| 巻・号 | 13 |
| 公開日 | 2025-6-18 |
| DOI | 10.7554/eLife.99825 |
| PII | 99825 |
| PMID | 40531176 |
| PMC | PMC12176390 |
| MeSH | Animals Ciona* / growth & development Ciona* / metabolism Ciona intestinalis* / growth & development Ciona intestinalis* / metabolism Cyclic AMP* / metabolism GTP-Binding Proteins* / metabolism Larva / growth & development Larva / metabolism Metamorphosis, Biological* Signal Transduction* |
| IF | 7.08 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| カタユウレイボヤ・(ニッポンウミシダ) | Wild C. int pSPCiPC2K pHTB-GCaMP8 |