Reference - Detail
| RRC ID | 85493 |
|---|---|
| Author | Mahata T, Kanarek K, Goren MG, Marimuthu Ragavan R, Bosis E, Qimron U, Salomon D. |
| Title | Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools. |
| Journal | Nat Microbiol |
| Abstract |
The evolutionary arms race between bacteria and phages led to the emergence of bacterial immune systems whose diversity and dynamics remain poorly understood. Here we use comparative genomics to describe a widespread genetic element, defined by the presence of the Gamma-Mobile-Trio (GMT) proteins, that serves as a reservoir of offensive and defensive tools. We demonstrate, using Vibrio parahaemolyticus as a model, that GMT-containing genomic islands are active mobile elements. Furthermore, we show that GMT islands' cargoes contain various anti-phage defence systems, antibacterial type VI secretion system (T6SS) effectors and antibiotic-resistance genes. We reveal four anti-phage defence systems encoded within GMT islands and further characterize one system, GAPS1, showing it is triggered by a phage capsid protein to induce cell dormancy. Our findings underscore the need to broaden the concept of 'defence islands' to include defensive and offensive tools, as both share the same mobile elements for dissemination. |
| Volume | 9(12) |
| Pages | 3268-3283 |
| Published | 2024-12-1 |
| DOI | 10.1038/s41564-024-01840-5 |
| PII | 10.1038/s41564-024-01840-5 |
| PMID | 39443754 |
| MeSH | Bacterial Proteins / genetics Bacterial Proteins / metabolism Bacteriophages* / genetics Bacteriophages* / physiology Genome, Bacterial Genomic Islands* Genomics Interspersed Repetitive Sequences* / genetics Type VI Secretion Systems / genetics Type VI Secretion Systems / metabolism Vibrio parahaemolyticus* / genetics |
| IF | 15.54 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 111 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic bacteria | |