| RRC ID |
85494
|
| 著者 |
Zhou Y, Chang J, Li F, He M, Li R, Hou Y, Zhang Y, Lu R, Yang M.
|
| タイトル |
H-NS-Mediated Regulation of Swimming Motility and Polar Flagellar Gene Expression in Vibrio parahaemolyticus.
|
| ジャーナル |
Curr Microbiol
|
| Abstract |
Vibrio parahaemolyticus is equipped with two distinct flagellar systems: a polar flagellum and numerous lateral flagella. The polar flagellum plays a role in propelling swimming in liquids, while the lateral flagella serve to enhance swarming on surfaces or in viscous environments. H-NS is a histone-like nucleoid structuring protein that plays a regulatory role in both the swimming and swarming motility of V. parahaemolyticus. However, the detailed mechanisms have not been fully understood. In this study, we have demonstrated that the deletion of hns hindered the growth rate of V. parahaemolyticus during the logarithmic growth phase and significantly decreased the swimming motility. H-NS directly activated the transcription of flgMN, flgAMN, flgBCDEFGHIJ, and flgKL-flaC located within the polar flagellar gene clusters. The expression of H-NS in Escherichia coli led to a marked elevation in the expression levels of flgM, flgA, flgB, and flgK, suggesting the positive effect of H-NS on the expression of polar flagellar genes in E. coli. This work demonstrates that the positive regulation of H-NS on the swimming motility in V. parahaemolyticus may be achieved through its regulation of polar flagellar gene expression and bacterial growth.
|
| 巻・号 |
82(1)
|
| ページ |
5
|
| 公開日 |
2024-11-23
|
| DOI |
10.1007/s00284-024-03993-2
|
| PII |
10.1007/s00284-024-03993-2
|
| PMID |
39579231
|
| MeSH |
Bacterial Proteins* / genetics
Bacterial Proteins* / metabolism
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
Escherichia coli / genetics
Escherichia coli / growth & development
Escherichia coli / metabolism
Escherichia coli / physiology
Flagella* / genetics
Flagella* / metabolism
Gene Expression Regulation, Bacterial*
Vibrio parahaemolyticus* / genetics
Vibrio parahaemolyticus* / growth & development
Vibrio parahaemolyticus* / physiology
|
| IF |
1.746
|
| リソース情報 |
| 病原細菌 |
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