論文 - 詳細
| RRC ID | 85495 |
|---|---|
| 著者 | Schiffmann S, Mass S, Salomon D. |
| タイトル | Bile acids activate the antibacterial T6SS1 in the gut pathogen Vibrio parahaemolyticus. |
| ジャーナル | Microbiol Spectr |
| Abstract |
The marine bacterium Vibrio parahaemolyticus is a major cause of seafood-borne gastroenteritis in humans and of acute hepatopancreatic necrosis disease in shrimp. Bile acids, produced by the host and modified into secondary bile acids by commensal bacteria in the gastrointestinal tract, induce the virulence factors leading to disease in humans and shrimp. Here, we show that secondary bile acids also activate this pathogen's type VI secretion system 1, a toxin delivery apparatus mediating interbacterial competition. This finding implies that Vibrio parahaemolyticus exploits secondary bile acids to activate its virulence factors and identify the presence of commensal bacteria that it needs to outcompete in order to colonize the host.IMPORTANCEBacterial pathogens often manipulate their host and cause disease by secreting toxic proteins. However, to successfully colonize a host, they must also remove commensal bacteria that reside in it and may compete with them over resources. Here, we find that the same host-derived molecules that activate the secreted virulence toxins in a gut bacterial pathogen, Vibrio parahaemolyticus, also activate an antibacterial toxin delivery system that targets such commensal bacteria. These findings suggest that a pathogen can use one cue to launch a coordinated, trans-kingdom attack that enables it to colonize a host. |
| 巻・号 | 12(10) |
| ページ | e0118124 |
| 公開日 | 2024-10-3 |
| DOI | 10.1128/spectrum.01181-24 |
| PMID | 39162543 |
| PMC | PMC11448226 |
| MeSH | Animals Anti-Bacterial Agents / pharmacology Bacterial Proteins / genetics Bacterial Proteins / metabolism Bile Acids and Salts* / metabolism Bile Acids and Salts* / pharmacology Gastrointestinal Microbiome Gastrointestinal Tract / microbiology Humans Penaeidae / microbiology Type VI Secretion Systems* / genetics Type VI Secretion Systems* / metabolism Vibrio Infections* / microbiology Vibrio parahaemolyticus* / drug effects Vibrio parahaemolyticus* / genetics Vibrio parahaemolyticus* / metabolism Vibrio parahaemolyticus* / pathogenicity Virulence Virulence Factors* / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原細菌 | JNBP_30766(RIMD 2210633) |