Reference - Detail
| RRC ID | 85527 |
|---|---|
| Author | Lee JH, Kim DY. |
| Title | 25-hydroxysterol mitigates microgravity-induced retinal damage by suppressing microglial inflammation through disrupting lipid raft formation. |
| Journal | NPJ Microgravity |
| Abstract |
Spaceflight-associated neuro-ocular syndrome (SANS) poses a significant risk to astronaut vision during long-duration missions, yet its immunological underpinnings remain poorly defined. Here, we identify retinal microglia as key mediators of ocular degeneration under simulated microgravity (SMG). Using a 3D clinostat model, we show that SMG induces early activation of retinal pigment epithelium (RPE), which in turn promotes microglial activation and triggers a feedforward cascade of RPE damage and neuronal loss. We further demonstrate that 25-hydroxycholesterol (25-HC), an oxysterol capable of penetrating the blood-retinal barrier, attenuates this inflammatory cascade by disrupting lipid raft formation in microglia. Low-dose 25-HC suppresses the recruitment of cytokine receptors to lipid rafts, mitigating microglia-driven retinal injury. These findings uncover a critical immunopathological axis underlying SANS and propose 25-HC as a non-invasive, immunomodulatory countermeasure to preserve retinal integrity during spaceflight. |
| Volume | 11(1) |
| Pages | 49 |
| Published | 2025-8-1 |
| DOI | 10.1038/s41526-025-00507-7 |
| PII | 10.1038/s41526-025-00507-7 |
| PMID | 40750775 |
| PMC | PMC12316943 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | pET28/His6-EGFP-D4 (RDB13961) |