論文 - 詳細
| RRC ID | 85679 |
|---|---|
| 著者 | Zhang X, Liu H, Wu X, Jia L, Gadhave K, Wang L, Zhang K, Li H, Chen R, Kumbhar R, Wang N, Terrillion CE, Kang BG, Bai B, Park M, Denna MCF, Zhang S, Zheng W, Ye D, Rong X, Yang L, Niu L, Ko HS, Peng W, Jin L, Ying M, Rosenthal LS, Nauen DW, Pantelyat A, Kaur M, Irene K, Shi L, Feleke R, García-Ruiz S, Ryten M, Dawson VL, Dominici F, Weber RJ, Zhang X, Liu P, Dawson TM, Han S, Mao X. |
| タイトル | Lewy body dementia promotion by air pollutants. |
| ジャーナル | Science |
| Abstract |
Evidence links air pollution to dementia, yet its role in Lewy body dementia (LBD) remains unclear. In this work, we showed in a cohort of 56.5 million individuals across the United States that fine particulate matter (PM2.5) exposure raises LBD risk. Mechanistically, we found that PM2.5 exposure led to brain atrophy in wild-type mice, an effect not seen in α-synuclein (αSyn)-deficient mice. PM2.5 exposure generated a highly pathogenic αSyn strain, PM2.5-induced preformed fibril (PM-PFF), with enhanced proteinase K resistance and neurotoxicity, resembling αSyn LBD strains. PM2.5 samples from China, the United States, and Europe consistently induced proteinase-resistant αSyn strains and in vivo pathology. Transcriptomic analyses revealed shared responses between PM2.5-exposed mice and LBD patients, underscoring PM2.5's role in LBD and stressing the need for interventions to reduce air pollution and its associated neurological disease burden. |
| 巻・号 | 389(6764) |
| ページ | eadu4132 |
| 公開日 | 2025-9-4 |
| DOI | 10.1126/science.adu4132 |
| PMID | 40906862 |
| MeSH | Aged Air Pollutants* / adverse effects Air Pollutants* / toxicity Air Pollution / adverse effects Animals Atrophy Brain* / drug effects Brain* / metabolism Brain* / pathology China Environmental Exposure* / adverse effects Female Humans Incidence Lewy Body Disease* / chemically induced Lewy Body Disease* / epidemiology Lewy Body Disease* / genetics Lewy Body Disease* / pathology Male Mice Particulate Matter* / adverse effects Particulate Matter* / toxicity United States / epidemiology alpha-Synuclein* / genetics alpha-Synuclein* / metabolism |
| IF | 41.846 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 760 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 54.5 |
| リソース情報 | |
| 実験動物マウス | RBRC10043 |