論文 - 詳細
| RRC ID | 85708 |
|---|---|
| 著者 | Horiguchi H, Kadomatsu T, Yamashita T, Yumoto S, Horino T, Sato M, Terada K, Miyata K, Ichigozaki Y, Kimura T, Fukushima S, Moroishi T, Oike Y. |
| タイトル | Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy. |
| ジャーナル | Cancer Gene Ther |
| Abstract |
Use of immune checkpoint inhibitors (ICIs) as cancer immunotherapy has advanced rapidly in the clinic. We recently reported that tumor stroma-derived angiopoietin-like protein 2 (ANGPTL2) has tumor suppressive activity by enhancing dendritic cell-mediated CD8+ T cell anti-tumor immune responses. However, a direct impact of ANGPTL2 on ICI anti-tumor effect remains unclear. Here, we use a murine syngeneic model to show that host ANGPTL2 facilitates CD8+ T cell cross-priming and contributes to anti-tumor responses to ICIs in this context. Importantly, our analysis of public datasets indicated that ANGPTL2 expression is associated with positive responses to ICI therapy by human melanoma patients. We conclude that ANGPTL2-mediated stromal cell crosstalk facilitates anti-tumor immunity and ICI responsiveness. These findings overall provide novel insight into ANGPTL2 anti-tumor function and regulation of ICI-induced anti-tumor immunity. |
| 巻・号 | 31(6) |
| ページ | 933-940 |
| 公開日 | 2024-6-1 |
| DOI | 10.1038/s41417-024-00757-9 |
| PII | 10.1038/s41417-024-00757-9 |
| PMID | 38467764 |
| MeSH | Angiopoietin-Like Protein 2* Angiopoietin-like Proteins / genetics Angiopoietin-like Proteins / metabolism Animals CD8-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / metabolism Cell Line, Tumor Female Humans Immune Checkpoint Inhibitors* / pharmacology Immune Checkpoint Inhibitors* / therapeutic use Melanoma / drug therapy Melanoma / genetics Melanoma / immunology Melanoma / metabolism Mice Mice, Inbred C57BL Stromal Cells / immunology Stromal Cells / metabolism Tumor Microenvironment / immunology |
| IF | 4.534 |
| リソース情報 | |
| ヒト・動物細胞 | B16F10(RCB2630) |