Reference - Detail
| RRC ID | 85742 |
|---|---|
| Author | Liang W, Ding J, Chai Q, Lv M, Zheng S, Cao X, Wang Z, Ying X, Wu W, Li G, Zhu M. |
| Title | H2A.Z primes an epigenetic landscape for memory CD8+ T cell recall response. |
| Journal | Nat Commun |
| Abstract |
The rapid recall ability is a hallmark of memory CD8+ T cells, but the underlying mechanisms remain incompletely understood. Here we find that histone variant H2A.Z is expressed at higher levels in memory CD8+ T cells than in naïve cells. Furthermore, in memory CD8+ T cells H2A.Z is deposited at the promoters and enhancers, particularly super enhancers, of those genes involved in recall responses, while H2A.Z deficiency in memory CD8+ T cells inhibits recall responses in vitro and in vivo. Mechanistically, multi-omics analyses show that H2A.Z maintains a poised epigenetic landscape on those recall response genes to potentiate a rapid transcription activation. Accordingly, H2A.Z deposition on these genes is induced by TCR/CD28 signals, and is cooperated by IL-7/IL-15 signals. Together, our data suggest that H2A.Z may orchestrate a specific epigenetic landscape during memory T cell differentiation to facilitate a rapid recall response. |
| Volume | 16(1) |
| Pages | 7625 |
| Published | 2025-8-15 |
| DOI | 10.1038/s41467-025-62976-4 |
| PII | 10.1038/s41467-025-62976-4 |
| PMID | 40817373 |
| PMC | PMC12356978 |
| MeSH | Animals CD28 Antigens / immunology CD28 Antigens / metabolism CD8-Positive T-Lymphocytes* / immunology CD8-Positive T-Lymphocytes* / metabolism Cell Differentiation / genetics Cell Differentiation / immunology Epigenesis, Genetic* Histones* / genetics Histones* / immunology Histones* / metabolism Immunologic Memory* / genetics Interleukin-15 / metabolism Memory T Cells* / immunology Memory T Cells* / metabolism Mice Mice, Inbred C57BL Mice, Knockout Promoter Regions, Genetic Receptors, Antigen, T-Cell / metabolism |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 8 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC05765 |