| RRC ID |
85742
|
| Author |
Liang W, Ding J, Chai Q, Lv M, Zheng S, Cao X, Wang Z, Ying X, Wu W, Li G, Zhu M.
|
| Title |
H2A.Z primes an epigenetic landscape for memory CD8+ T cell recall response.
|
| Journal |
Nat Commun
|
| Abstract |
The rapid recall ability is a hallmark of memory CD8+ T cells, but the underlying mechanisms remain incompletely understood. Here we find that histone variant H2A.Z is expressed at higher levels in memory CD8+ T cells than in naïve cells. Furthermore, in memory CD8+ T cells H2A.Z is deposited at the promoters and enhancers, particularly super enhancers, of those genes involved in recall responses, while H2A.Z deficiency in memory CD8+ T cells inhibits recall responses in vitro and in vivo. Mechanistically, multi-omics analyses show that H2A.Z maintains a poised epigenetic landscape on those recall response genes to potentiate a rapid transcription activation. Accordingly, H2A.Z deposition on these genes is induced by TCR/CD28 signals, and is cooperated by IL-7/IL-15 signals. Together, our data suggest that H2A.Z may orchestrate a specific epigenetic landscape during memory T cell differentiation to facilitate a rapid recall response.
|
| Volume |
16(1)
|
| Pages |
7625
|
| Published |
2025-8-15
|
| DOI |
10.1038/s41467-025-62976-4
|
| PII |
10.1038/s41467-025-62976-4
|
| PMID |
40817373
|
| PMC |
PMC12356978
|
| MeSH |
Animals
CD28 Antigens / immunology
CD28 Antigens / metabolism
CD8-Positive T-Lymphocytes* / immunology
CD8-Positive T-Lymphocytes* / metabolism
Cell Differentiation / genetics
Cell Differentiation / immunology
Epigenesis, Genetic*
Histones* / genetics
Histones* / immunology
Histones* / metabolism
Immunologic Memory* / genetics
Interleukin-15 / metabolism
Memory T Cells* / immunology
Memory T Cells* / metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Promoter Regions, Genetic
Receptors, Antigen, T-Cell / metabolism
|
| IF |
12.121
|
| Resource |
| Mice |
RBRC05765 |
