Reference - Detail
| RRC ID | 85882 |
|---|---|
| Author | Aoki K, Yoshitani N, Kurio N, Yoshioka N, Teramachi J, Ikegame M, Okamura H, Ibaragi S. |
| Title | Angiogenin-induced Osteoclastogenesis Mediates Bone Destruction in Oral Squamous Carcinoma. |
| Journal | Anticancer Res |
| Abstract |
BACKGROUND/AIM:Bone destruction caused by oral cancer severely impacts patient quality of life. This study aimed to clarify the role of angiogenin (ANG) in osteoclastogenesis and oral cancer-induced bone destruction. MATERIALS AND METHODS:Recombinant ANG was used to assess its effects on osteoclast formation and bone resorption activity in bone marrow cultures. ANG-knockdown oral squamous carcinoma HSC-2 cells (ANG-RNAi) were transplanted into intramedullary cavities of femurs. Bone destruction was radiologically analyzed, while angiogenesis and osteoclast induction in the surrounding area of the transplanted lesion were histologically examined. RESULTS:Recombinant ANG promoted osteoclast formation and bone resorption activity. Transplantation of ANG-RNAi cells significantly reduced tumor growth and bone destruction properties compared to transplantation of control cells. Histological analysis revealed lower angiogenesis and fewer osteoclast induction in the ANG-RNAi cells-transplanted group. CONCLUSION:ANG mediates oral cancer-induced bone destruction by promoting osteoclast formation and resorption. These findings suggest that ANG could be a potential therapeutic target for suppressing tumor growth, angiogenesis, and bone destruction in oral cancer therapy. |
| Volume | 45(3) |
| Pages | 1025-1033 |
| Published | 2025-3-1 |
| DOI | 10.21873/anticanres.17489 |
| PII | 45/3/1025 |
| PMID | 40037849 |
| MeSH | Animals Bone Resorption* / metabolism Bone Resorption* / pathology Carcinoma, Squamous Cell* / genetics Carcinoma, Squamous Cell* / metabolism Carcinoma, Squamous Cell* / pathology Cell Line, Tumor Humans Male Mice Mouth Neoplasms* / genetics Mouth Neoplasms* / metabolism Mouth Neoplasms* / pathology Neovascularization, Pathologic / pathology Osteoclasts* / drug effects Osteoclasts* / metabolism Osteoclasts* / pathology Osteogenesis* / drug effects Ribonuclease, Pancreatic* / genetics Ribonuclease, Pancreatic* / metabolism |
| IF | 1.994 |
| Resource | |
| Human and Animal Cells | HSC-2(RCB1945) |