論文 - 詳細
| RRC ID | 85917 |
|---|---|
| 著者 | Tanaka E, Hirai Y, Wajima T, Ishida Y, Kawamura Y, Nakaminami H. |
| タイトル | High-Level Quinolone-Resistant Haemophilus haemolyticus in Pediatric Patient with No History of Quinolone Exposure. |
| ジャーナル | Emerg Infect Dis |
| Abstract |
The prevalence of antimicrobial resistance among Haemophilus spp. is a critical concern, but high-level quinolone-resistant strains had not been isolated from children. We isolated high-level quinolone-resistant H. haemolyticus from the suction sputum of a 9-year-old patient. The patient had received home medical care with mechanical ventilation for 2 years and had not been exposed to any quinolones for >3 years. The H. haemolyticus strain we isolated, 2019-19, shared biochemical features with H. influenzae. However, whole-genome analysis found this strain was closer to H. haemolyticus. Phylogenetic and mass spectrometry analyses indicated that strain 2019-19 was in the same cluster as H. haemolyticus. Comparison of quinolone resistance-determining regions showed strain 2019-19 possessed various amino acid substitutions, including those associated with quinolone resistance. This report highlights the existence of high-level quinolone-resistant Haemophilus species that have been isolated from both adults and children. |
| 巻・号 | 28(1) |
| ページ | 104-110 |
| 公開日 | 2022-1-1 |
| DOI | 10.3201/eid2801.210248 |
| PMID | 34932443 |
| PMC | PMC8714209 |
| MeSH | Adult Anti-Bacterial Agents / pharmacology Anti-Bacterial Agents / therapeutic use Child Haemophilus / genetics Haemophilus Infections* / drug therapy Haemophilus influenzae Humans Phylogeny Quinolones* / pharmacology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原細菌 | JNBP_02667 JNBP_02643 |