| RRC ID |
85917
|
| Author |
Tanaka E, Hirai Y, Wajima T, Ishida Y, Kawamura Y, Nakaminami H.
|
| Title |
High-Level Quinolone-Resistant Haemophilus haemolyticus in Pediatric Patient with No History of Quinolone Exposure.
|
| Journal |
Emerg Infect Dis
|
| Abstract |
The prevalence of antimicrobial resistance among Haemophilus spp. is a critical concern, but high-level quinolone-resistant strains had not been isolated from children. We isolated high-level quinolone-resistant H. haemolyticus from the suction sputum of a 9-year-old patient. The patient had received home medical care with mechanical ventilation for 2 years and had not been exposed to any quinolones for >3 years. The H. haemolyticus strain we isolated, 2019-19, shared biochemical features with H. influenzae. However, whole-genome analysis found this strain was closer to H. haemolyticus. Phylogenetic and mass spectrometry analyses indicated that strain 2019-19 was in the same cluster as H. haemolyticus. Comparison of quinolone resistance-determining regions showed strain 2019-19 possessed various amino acid substitutions, including those associated with quinolone resistance. This report highlights the existence of high-level quinolone-resistant Haemophilus species that have been isolated from both adults and children.
|
| Volume |
28(1)
|
| Pages |
104-110
|
| Published |
2022-1-1
|
| DOI |
10.3201/eid2801.210248
|
| PMID |
34932443
|
| PMC |
PMC8714209
|
| MeSH |
Adult
Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Child
Haemophilus / genetics
Haemophilus Infections* / drug therapy
Haemophilus influenzae
Humans
Phylogeny
Quinolones* / pharmacology
|
| Resource |
| Pathogenic bacteria |
JNBP_02667
JNBP_02643 |
