論文 - 詳細
| RRC ID | 85997 |
|---|---|
| 著者 | Kumai J, Sasagawa S, Yui Y. |
| タイトル | Metastatic breast cancer cells adapt to a soft environment with limited involvement of mechanotransduction. |
| ジャーナル | Exp Cell Res |
| Abstract |
The extracellular matrix (ECM) plays a crucial role in regulating intracellular signaling in tumor cells. Although the influence of ECM stiffness on tumor malignancy has been well studied, the adaptation of tumors to a soft extratumoral environment with an increasing proliferation rate remains poorly understood. In this study, we investigated the mechanism of tumor cell adaptation to a soft environment and its relationship with tumor malignancy. A soft extracellular environment was required for adaptation. Among the various cell lines, highly malignant cancer cells, such as MDA-MB-231, PC3 and KP4, demonstrated an adaptive response to soft environments, as evidenced by increased cell extension and proliferation. Furthermore, adaptation to a soft environment enhanced lung colonization in a mouse model of breast cancer, suggesting a potential link between adaptability to soft environments and accelerated tumor malignancy. The mechanical environment of the cells before being transferred to a softer environment affected their adaptation as a mechanical memory via histone modifications. Integrin β1-mediated adhesion to the ECM played a central role in this adaptive phenomenon. Interestingly, adaptation occurred through a mechanism with limited involvement of mechanotransduction and prominent enhancement of ribosomal activity, providing new insights into the proliferation mechanisms in a soft environment. This study revealed how tumor cells adapt to a soft environment and showed that the adaptation phenomenon may be related to malignant transformation. Thus, the adaptation mechanism may be a therapeutic target for the suppression of metastasis. |
| 巻・号 | 450(2) |
| ページ | 114629 |
| 公開日 | 2025-7-15 |
| DOI | 10.1016/j.yexcr.2025.114629 |
| PII | S0014-4827(25)00225-3 |
| PMID | 40466802 |
| MeSH | Adaptation, Physiological* Animals Breast Neoplasms* / metabolism Breast Neoplasms* / pathology Cell Adhesion Cell Line, Tumor Cell Proliferation Extracellular Matrix / metabolism Extracellular Matrix / pathology Female Humans Integrin beta1 / metabolism Lung Neoplasms / secondary Mechanotransduction, Cellular* / physiology Mice Neoplasm Metastasis Tumor Microenvironment |
| IF | 3.383 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MDA-MB-453(RCB1192) KP4(RCB1005) PANC1(RCB2095) |