論文 - 詳細
| RRC ID | 86004 |
|---|---|
| 著者 | Saito H, Chan JY, Omori I, Iwasawa O, Sugimori A, Nakajima H, Ichimura R, Sato S, Sumida H. |
| タイトル | IL-13/IL-13Rα2 axis promotes proliferation of angiosarcoma cells. |
| ジャーナル | Sci Rep |
| Abstract |
Angiosarcoma is a rare and aggressive soft tissue sarcoma with a poor prognosis and limited treatment options. The role of interleukin-13 (IL-13) and its receptors in angiosarcoma pathogenesis has been largely unknown. We first reanalyzed transcriptomic data from a published angiosarcoma cohort and found IL13RA2 mRNA elevated in angiosarcoma versus normal tissue. In addition, high IL13RA2 expression was significantly associated with increased nonsynonymous mutations. We next detected high IL-13 receptor α2 (IL-13Rα2) expression in angiosarcoma cell lines and patient samples compared to other cell types and benign vascular tumors. Moreover, histological analysis showed the presence of IL-13 in the angiosarcoma microenvironment. Functional studies using angiosarcoma cell lines, MO-LAS-B cells, revealed the promoting effect of IL-13 on cell proliferation. The effect was inhibited by siRNA-mediated knockdown of IL13RA2 or neutralizing antibodies against IL-13, suggesting the impact of IL-13/IL-13Rα2 axis in the angiosarcoma proliferation. In addition, IL-13 stimulation increased mRNA levels of IL13RA2 and VEGFA, suggesting an underlying positive feedback mechanism, which was attenuated by a STAT6 inhibitor. These findings highlight the importance of the IL-13/IL-13Rα2 axis in angiosarcoma progression and its potential as a novel therapeutic target for this challenging malignancy. |
| 巻・号 | 15(1) |
| ページ | 31236 |
| 公開日 | 2025-8-25 |
| DOI | 10.1038/s41598-025-15933-6 |
| PII | 10.1038/s41598-025-15933-6 |
| PMID | 40855097 |
| PMC | PMC12379233 |
| MeSH | Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic Hemangiosarcoma* / genetics Hemangiosarcoma* / metabolism Hemangiosarcoma* / pathology Humans Interleukin-13* / genetics Interleukin-13* / metabolism Interleukin-13 Receptor alpha2 Subunit* / genetics Interleukin-13 Receptor alpha2 Subunit* / metabolism Signal Transduction Tumor Microenvironment |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | A431(RCB0202) |