論文 - 詳細
| RRC ID | 86083 |
|---|---|
| 著者 | Azumi J, Takeda T, Shibata S, Shimada Y, Aso H, Nakamura T. |
| タイトル | The Organogermanium Compound 3-(trihydroxygermyl)propanoic Acid Exerts Anti-Inflammatory Effects via Adenosine-NR4A2 Signaling. |
| ジャーナル | Int J Mol Sci |
| Abstract |
We previously reported that 3-(trihydroxygermyl)propanoic acid (THGP) suppresses inflammasome activation in THP-1 cells following stimulation with lipopolysaccharide (LPS) and ATP (signals 1 and 2) by forming a complex with ATP, thereby inhibiting IL-1β secretion. Our findings also suggested that THGP inhibits inflammasome activation through mechanisms independent of ATP complex formation. This study investigated the anti-inflammatory effects of THGP on signal 1 (ATP-independent) of inflammasome activation. THGP suppressed NF-κB nuclear translocation in LPS-stimulated THP-1 cells, which reduced the mRNA expression of the proinflammatory cytokines TNF-α and IL-6, as well as IL-1β secretion. This mechanism was mediated by the formation of a THGP-adenosine complex, which inhibited adenosine degradation and subsequently activated adenosine-NR4A2 signaling. Thus, THGP exerts anti-inflammatory effects by forming a complex with adenosine, leading to adenosine-NR4A2 signaling pathway activation. This mechanism is distinct from the ATP-dependent pathway by which THGP was previously reported to function. By targeting both ATP-dependent and ATP-independent inflammasome activation pathways, THGP has potential as a broad-spectrum therapeutic agent for various inflammatory diseases. |
| 巻・号 | 26(6) |
| 公開日 | 2025-3-9 |
| DOI | 10.3390/ijms26062449 |
| PII | ijms26062449 |
| PMID | 40141094 |
| PMC | PMC11941763 |
| MeSH | Adenosine* / metabolism Adenosine Triphosphate / metabolism Anti-Inflammatory Agents* / chemistry Anti-Inflammatory Agents* / pharmacology Humans Inflammasomes / drug effects Inflammasomes / metabolism Lipopolysaccharides / pharmacology NF-kappa B / metabolism Signal Transduction* / drug effects THP-1 Cells |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | THP-1 |