論文 - 詳細
| RRC ID | 86086 |
|---|---|
| 著者 | Futamura Y, Yamamoto K, Uson-Lopez R, Aono H, Shimizu T, Hori Y, Kino K, Osada H. |
| タイトル | Inhibitory effect of copper chelators on the budding in Candida albicans. |
| ジャーナル | Antimicrob Agents Chemother |
| Abstract |
Candida albicans exhibits a unique dimorphic behavior, allowing it to switch between unicellular budding yeast and filamentous hyphal growth. This dimorphism is crucial for its pathogenicity, influencing processes such as adhesion, invasion, immune evasion, and host response. A comprehensive understanding of the molecular mechanisms governing yeast and hyphal growth, as well as the switch between these forms, is crucial for the development of effective anticandidal therapies. In this study, we screened for small molecules that interfere with the dimorphism of C. albicans and identified the actinomycete metabolite RK-276A/SF2768 as a potent inhibitor of this process. Time-lapse microscopy revealed that SF2768 inhibited hyphal branching and lateral yeast budding during the hyphal-to-yeast transition. Interestingly, SF2768 also suppressed farnesol-induced yeast growth by inhibiting yeast bud formation. The effects of SF2768 were canceled with copper addition, and other copper chelators, such as trientine and d-penicillamine, induced similar phenotypes, indicating that the copper-chelating activity of SF2768 is crucial for its antifungal properties. Furthermore, copper ions induced both hyphal and yeast bud formation. These findings strongly suggest that copper ions play a role in Candida budding, and the copper chelators could be developed as novel antifungal agents against not only dimorphic Candida spp. but also non-dimorphic Candida spp. |
| 巻・号 | 69(5) |
| ページ | e0003325 |
| 公開日 | 2025-5-7 |
| DOI | 10.1128/aac.00033-25 |
| PMID | 40202341 |
| PMC | PMC12057359 |
| MeSH | Antifungal Agents* / pharmacology Candida albicans* / drug effects Candida albicans* / growth & development Candida albicans* / metabolism Chelating Agents* / pharmacology Copper* / metabolism Copper* / pharmacology Farnesol / pharmacology Hyphae / drug effects Hyphae / growth & development Microbial Sensitivity Tests |
| IF | 4.904 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |