論文 - 詳細
| RRC ID | 86092 |
|---|---|
| 著者 | Boscolo D, Lovatti G, Sokol O, Vitacchio T, Moglioni M, Evangelista F, Haettner E, Tinganelli W, Graeff C, Weber U, Schuy C, Nitta M, Kostyleva D, Purushothaman S, Thirolf PG, Bückner A, Bortfeldt J, Scheidenberger C, Parodi K, Durante M. |
| タイトル | Image-guided treatment of mouse tumours with radioactive ion beams. |
| ジャーナル | Nat Phys |
| Abstract |
Charged particle therapy with protons or heavier ions is one of the most effective radiotherapy techniques, but uncertainties in the beam range can limit its efficacy. Radioactive ion beams are ideal for image-guided particle therapy because isotopes that undergo β+ decay can be visualized with positron emission tomography. This allows spatial localization of the particle distribution in vivo, which can be correlated with the expected dose deposition for online beam range verification. Here we report the successful treatment of a mouse osteosarcoma using a radioactive 11C-ion beam. The tumour was located in the neck, close to the spinal cord, where deviations of even a few millimetres in the beam range could lead to unintended dose deposition in the spine and radiation-induced myelopathy, an injury to the spinal cord. We achieved complete tumour control with the highest dose of 20 Gy while avoiding paralysis. Low-grade neurological side effects were correlated to the activity measured by positron emission tomography in the spine. The biological washout of the activity from the tumour volume was dependent on the dose, indicating a potential component of vascular damage at high doses. This experiment marks a step towards future clinical applications of radioactive ion beams. |
| 巻・号 | 21(10) |
| ページ | 1648-1656 |
| 公開日 | 2025-1-1 |
| DOI | 10.1038/s41567-025-02993-8 |
| PII | 2993 |
| PMID | 41098546 |
| PMC | PMC12518140 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 33 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.8 |
| リソース情報 | |
| ヒト・動物細胞 | LM8(RCB1450) |