| RRC ID |
86098
|
| 著者 |
Yamada K, Suga K, Abe N, Hashimoto K, Tsutsumi S, Inagaki M, Hashiya F, Abe H, Hamada M.
|
| タイトル |
Multi-objective computational optimization of human 5' UTR sequences.
|
| ジャーナル |
Brief Bioinform
|
| Abstract |
The computational design of messenger RNA (mRNA) sequences is a critical technology for both scientific research and industrial applications. Recent advances in prediction and optimization models have enabled the automatic scoring and optimization of $5^\prime $ UTR sequences, key upstream elements of mRNA. However, fully automated design of $5^\prime $ UTR sequences with more than two objective scores has not yet been explored. In this study, we present a computational pipeline that optimizes human $5^\prime $ UTR sequences in a multi-objective framework, addressing up to four distinct and conflicting objectives. Our work represents an important advancement in the multi-objective computational design of mRNA sequences, paving the way for more sophisticated mRNA engineering.
|
| 巻・号 |
26(3)
|
| 公開日 |
2025-5-1
|
| DOI |
10.1093/bib/bbaf225
|
| PII |
8148684
|
| PMID |
40413870
|
| PMC |
PMC12103902
|
| MeSH |
5' Untranslated Regions*
Algorithms
Base Sequence
Computational Biology* / methods
Humans
RNA, Messenger / genetics
Sequence Analysis, RNA* / methods
|
| IF |
8.99
|
| リソース情報 |
| ヒト・動物細胞 |
293T(RCB2202) |
