論文 - 詳細
| RRC ID | 86134 |
|---|---|
| 著者 | Watanabe A, Lu J, Ishihara K, Iwabuchi S, Ohno K, Hashimoto S, Asakage T, Takahashi K, Podyma-Inoue KA, Watabe T. |
| タイトル | UBE2T promotes epithelial-mesenchymal transition and motility in oral cancer cells via induction of IL-6 expression. |
| ジャーナル | Oncol Lett |
| Abstract |
Oral squamous cell carcinoma (OSCC) is a prevalent aggressive malignancy with a high mortality rate. However, the mechanisms underlying the progression of OSCC remain to be elucidated. In the present study, bioinformatics analysis identified ubiquitin-conjugating enzyme E2 T (UBE2T) as a poor prognostic factor in head and neck cancer, showing the strongest association with cancer stage progression. Functional studies revealed that UBE2T can enhance motility and induce epithelial-mesenchymal transition (EMT) in OSCC cells. RNA sequencing and subsequent analyses demonstrated that UBE2T upregulated the expression levels of various motility- and EMT-related factors, including ankyrin repeat domain 1, endothelin-1, interleukin-6 (IL-6), matrix metalloproteinase-9 and plasminogen activator, urokinase. Gene set enrichment analysis indicated that UBE2T activates the IL-6/Janus protein tyrosine kinase (JAK)/signal transducer and activator of transcription 3 signaling pathway. Moreover, treatment of OSCC cells with IL-6 or a JAK inhibitor resulted in the induction of EMT and mesenchymal-epithelial transition, respectively, accompanied by enhanced and suppressed cancer cell motility. These results indicated that IL-6, which is upregulated by UBE2T, may be crucial for maintaining mesenchymal traits and motility in OSCC cells. Collectively, these findings suggested that the UBE2T/IL-6/JAK axis may serve as a potential therapeutic target for OSCC. |
| 巻・号 | 30(4) |
| ページ | 473 |
| 公開日 | 2025-10-1 |
| DOI | 10.3892/ol.2025.15219 |
| PII | OL-30-4-15219 |
| PMID | 40842469 |
| PMC | PMC12365892 |
| IF | 2.311 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | CSII-EF-RfA (RDB04387) pCMV-VSV-G-RSV-Rev (RDB04393) pCAG-HIVgp (RDB04394) |
| ヒト・動物細胞 | SAS(RCB1974) |