論文 - 詳細
| RRC ID | 86140 |
|---|---|
| 著者 | Tanikawa T, Hayashi T, Kiba Y, Kamauchi H, Someya Y, Kitamura M. |
| タイトル | Inhibitory effect of [6]-shogaol against 3CLpro activity and SARS-CoV-2 infection. |
| ジャーナル | BMC Complement Med Ther |
| Abstract |
BACKGROUND:Zingiber officinale Roscoe (ginger) has been traditionally used not only as a culinary ingredient, but also for its medicinal properties. In Japan, ginger-derived crude drugs are categorized into dried ginger (Zingiberis Rhizoma [ZR]) or steamed ginger (Zingiberis Rhizoma processum [ZR-P]). Heating ginger converts gingerol, the primary component of ZR, into shogaol. In this study, we aimed to evaluate the inhibitory effects of ginger and its constituents on SARS-CoV-2 infection. METHODS:We assessed the inhibitory effects of ZR, ZR-P, [6]-gingerol, and [6]-shogaol on SARS-CoV-2 infection in VeroE6/TMPRSS2 cells. To understand the molecular mechanism underlying this inhibitory effect, we evaluated the activity of [6]-shogaol against the viral proteases 3 C-like protease (3CLpro) and papain-like protease (PLpro). RESULTS:We observed that ZR-P (66.1% suppression at 50 µg/ml) and [6]-shogaol (70.0% suppression at 25 µM) exhibited significant inhibitory effects against SARS-CoV-2 infection. We found that [6]-shogaol effectively inhibited 3CLpro activities both in vitro (20.4% inhibition at 40 µM) and in FlipGFP reporter system (19.7% inhibition at 25 µM). CONCLUSIONS:This study highlights [6]-shogaol and ZR-P as promising natural inhibitors of SARS-CoV-2, providing new insights into the pharmacological potential of traditional ginger preparations and their active components against COVID-19. |
| 巻・号 | 25(1) |
| ページ | 385 |
| 公開日 | 2025-10-17 |
| DOI | 10.1186/s12906-025-05094-4 |
| PII | 10.1186/s12906-025-05094-4 |
| PMID | 41107840 |
| PMC | PMC12534974 |
| MeSH | Animals Antiviral Agents* / pharmacology COVID-19 COVID-19 Drug Treatment* Catechols* / pharmacology Chlorocebus aethiops Coronavirus 3C Proteases* / antagonists & inhibitors Fatty Alcohols / pharmacology Humans Plant Extracts* / pharmacology SARS-CoV-2* / drug effects Vero Cells Zingiber officinale* / chemistry |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |