論文 - 詳細
| RRC ID | 86290 |
|---|---|
| 著者 | Okamoto N, Mizuno Y, Watanabe A, Kohsaka H, Niwa R. |
| タイトル | Neuroendocrine control of calcium mobilization in the fruit fly. |
| ジャーナル | Nature |
| Abstract |
Calcium (Ca2+) is an essential mineral that must be strictly regulated to support numerous physiological activities1,2. Extracellular fluid Ca2+ is regulated in vertebrates through endocrine systems that manage the vast Ca2+ reservoir in the bones3-6, but the Ca2+ regulatory mechanisms used by invertebrates, which lack bones, remain largely unclear. Here we identified a potent peptide hormone, Capa, which is responsible for regulating extracellular fluid Ca2+ levels in the fruit fly Drosophila melanogaster. Capa-deficient larvae exhibit low haemolymph Ca2+ levels, resulting in reduced locomotion and induced elongated pupae that mimic those of animals reared on a Ca2+-free diet. Capa secreted from specific neurosecretory cells acts on specialized Ca2+ storage compartments in the anterior Malpighian tubules, elevating haemolymph Ca2+. This endocrine mechanism governing Ca2+ regulation in terrestrial invertebrates resembles the parathyroid hormone system in vertebrates. |
| 公開日 | 2025-10-22 |
| DOI | 10.1038/s41586-025-09670-z |
| PII | 10.1038/s41586-025-09670-z |
| PMID | 41125891 |
| IF | 42.779 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 223 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 1.7 |
| リソース情報 | |
| ショウジョウバエ | DGRC#112001 DGRC#103880 |