論文 - 詳細
| RRC ID | 86305 |
|---|---|
| 著者 | Yamaguchi Y, Maekawa Y, Kabashima K, Mizuno T, Tainaka M, Suzuki T, Dojo K, Tominaga T, Kuroiwa S, Masubuchi S, Doi M, Tominaga K, Kobayashi K, Yamagata S, Itoi K, Abe M, Schwartz WJ, Sakimura K, Okamura H. |
| タイトル | An intact pituitary vasopressin system is critical for building a robust circadian clock in the suprachiasmatic nucleus. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
The circadian clock is a biological timekeeping system that oscillates with a circa-24-h period, reset by environmental timing cues, especially light, to the 24-h day-night cycle. In mammals, a "central" clock in the hypothalamic suprachiasmatic nucleus (SCN) synchronizes "peripheral" clocks throughout the body to regulate behavior, metabolism, and physiology. A key feature of the clock's oscillation is resistance to abrupt perturbations, but the mechanisms underlying such robustness are not well understood. Here, we probe clock robustness to unexpected photic perturbation by measuring the speed of reentrainment of the murine locomotor rhythm after an abrupt advance of the light-dark cycle. Using an intersectional genetic approach, we implicate a critical role for arginine vasopressin pathways, both central within the SCN and peripheral from the anterior pituitary. |
| 巻・号 | 120(43) |
| ページ | e2308489120 |
| 公開日 | 2023-10-24 |
| DOI | 10.1073/pnas.2308489120 |
| PMID | 37844254 |
| PMC | PMC10614613 |
| MeSH | Animals Circadian Clocks* / genetics Circadian Rhythm / physiology Mammals / metabolism Mice Photoperiod Suprachiasmatic Nucleus / metabolism Vasopressins / metabolism |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC01835 RBRC01828 |