Reference - Detail
| RRC ID | 86369 |
|---|---|
| Author | Rojasawasthien T, Ito T, Okamoto H, Okumura N, Yamashita Takeuchi S, Shirakawa T, Matsubara T, Kokabu S. |
| Title | Sebacic acid promotes osteoblast differentiation. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
Royal jelly (RJ), secreted by honeybees, contains major fatty acids such as 10-hydroxy-2-decenoic acid and 10-hydroxydecanoic acid, which are considered to contribute to bone metabolism. However, these fatty acids are rapidly metabolized in the liver following ingestion, resulting in 2-decenoic acid (2DA) and sebacic acid (SA), respectively. Therefore, elucidating the roles of these metabolites in bone metabolism is of considerable importance. In this study, we focused and investigated the effects of 2DA and SA on osteoblast differentiation using osteoblast-lineage cells. SA treatment significantly upregulated the expression of osteoblast marker genes whereas 2DA had no apparent effect. In addition, SA enhanced alkaline phosphatase activity, a typical marker of osteoblast differentiation and mineralization. |
| Volume | 89(11) |
| Pages | 1572-1578 |
| Published | 2025-10-24 |
| DOI | 10.1093/bbb/zbaf128 |
| PII | 8248514 |
| PMID | 40911293 |
| MeSH | Alkaline Phosphatase / metabolism Animals Cell Differentiation* / drug effects Cell Line Decanoic Acids* / pharmacology Dicarboxylic Acids* / pharmacology Fatty Acids, Monounsaturated / metabolism Fatty Acids, Monounsaturated / pharmacology Mice Osteoblasts* / cytology Osteoblasts* / drug effects Osteoblasts* / metabolism Osteogenesis / drug effects |
| IF | 1.516 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 25 |
| Altmetric score changes over past 6months | 11.0 |
| Resource | |
| Human and Animal Cells | ST2(RCB0224) |