| RRC ID |
86436
|
| Author |
Ibraheem Y, Bayarsaikhan G, Macalinao ML, Kimura K, Yui K, Aoshi T, Inoue SI.
|
| Title |
γδ T cell-mediated activation of cDC1 orchestrates CD4+ Th1 cell priming in malaria.
|
| Journal |
Front Immunol
|
| Abstract |
γδ T cells facilitate the CD4+ T helper 1 (Th1) cell response against Plasmodium infection by activating conventional dendritic cells (cDCs), although the underlying mechanism remains elusive. Our study revealed that γδ T cells promote the complete maturation and production of interleukin-12 and CXCR3-ligands specifically in type 1 cDCs (cDC1), with minimal impact on cDC2 and monocyte derived DCs (Mo-DCs). During the initial infection phase, γδ T cell activation and temporal accumulation in the splenic white pulp, alongside cDC1, occur via CCR7-signaling. Furthermore, cDC1/γδ T cell interactions in the white pulp are amplified through CXCR3 signaling in γδ T cells, optimizing Th1 cell priming by cDC1. We also demonstrated how transitional Th1 cells arise in the white pulp before establishing their presence in the red pulp as fully differentiated Th1 cells. Additionally, we elucidate the reciprocal activation between γδ T cells and cDC1s. These findings suggest that Th1 cell priming is orchestrated by this reciprocal activation in the splenic white pulp during the early phase of blood-stage Plasmodium infection.
|
| Volume |
15
|
| Pages |
1426316
|
| Published |
2024-1-1
|
| DOI |
10.3389/fimmu.2024.1426316
|
| PMID |
39211036
|
| PMC |
PMC11357926
|
| MeSH |
Animals
Cell Differentiation / immunology
Dendritic Cells* / immunology
Dendritic Cells* / metabolism
Female
Lymphocyte Activation* / immunology
Malaria* / immunology
Malaria* / parasitology
Mice
Mice, Inbred C57BL
Receptors, Antigen, T-Cell, gamma-delta / immunology
Receptors, Antigen, T-Cell, gamma-delta / metabolism
Receptors, CCR7 / immunology
Receptors, CCR7 / metabolism
Receptors, CXCR3 / metabolism
Signal Transduction
Spleen / immunology
Th1 Cells* / immunology
|
| IF |
5.085
|
| Resource |
| Mice |
RBRC00407 |
